缺血性脑梗死与颈动脉斑块、嗜酸性粒细胞、血小板CD62p水平的临床相关性研究

Clinical correlation between acute ischemic stroke, eosinophil, carotid artery, plaque CD62p level

目的探讨急性缺血性脑梗死初发与再发与颈动脉斑块、嗜酸性粒细胞水平与血小板活化水平之间的相关性。方法本研究选取50例被诊断为急性缺血性脑梗死的患者,患者均进行颈部血管超声检查,根据有无颈动脉斑块分为2组,均进行嗜酸性粒细胞、血小板活性CD62p水平等指标检测。两组间比较采用t检验。结果有颈动脉斑块形成的急性缺血性脑梗死患者,其嗜酸性粒细胞计数低于无颈动脉斑块患者(P <0.05),而其血浆CD62p水平高于无颈动脉斑块患者(P <0.05),1年随访中复发率更高(P <0.05)。结论急性缺血性脑梗死患者的初发与复发与颈动脉斑块存在,嗜酸性粒细胞计数及CD62p水平密切相关。

Objective To investigate the correlation between eosinophil count, carotid plaque CD62p level and the prognosis of acute ischemic stroke. Methods 50 patients diagnosed as having acute ischemic stroke were include in this study. The patients were divided into 2 groups according to whether there were carotid plaques. All of them were examined by ultrasonography of neck vessels, eosinophil and CD62p level. The t test was used for comparison between the two groups. Results There was no significant difference in the baseline characteristics between two groups （P 〉 0.05）. Stroke patients with carotid plaque formation had a significantly lower eosinophil count than did patients without carotid artery plaque（P 〈0.05）, with a higher plasma level of CD62p （P〈 0.05） and more recurrence in 1 year follow-up（P 〈 0.05）. Conclusion Carotid plaque, the level of eosinophil and CD62p in acute ischemic stroke are closely related to the recurrence of the acute ischemic stroke.