养心定悸胶囊对围绝经期综合征患者相关激素及神经递质水平的影响

Effect of Yangxin Dingji Capsules on related hormone and neurotransmitter in patients with perimenopausal syndrome

目的探讨养心定悸胶囊对围绝经期综合征患者临床症状、相关激素及神经递质水平的影响。方法选取石家庄市第三医院2014年11月～2016年7月就诊的104例围绝经期综合征患者,根据随机数字表法分为对照组和研究组,每组各52例。对照组服用尼尔雌醇治疗,研究组在此基础上加服养心定悸胶囊,均持续治疗4周。比较两组患者的临床疗效。治疗前后评定Kupper-man评分量表、更年期生活质量评分量表(MRS)、抑郁自评量表(SDS),测定血清激素雌二醇(E_2)、卵泡刺激素(FSH)、黄体生成素(LH),以及神经递质5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)水平。记录两组不良反应发生情况。结果研究组总有效率为90.38%,显著高于对照组的75.00%(P<0.05)。与治疗前比较,治疗后两组患者的Kupper-man、MRS、SDS评分明显降低,且研究组明显低于对照组(P<0.01);血清激素中E_2水平明显升高,FSH、LH水平明显降低,且研究组改善更为显著(P<0.01);血清神经递质水平中5-HT、NE、DA水平明显升高,且研究组明显高于对照组(P<0.01)。结论养心定悸胶囊能够显著改善围绝经期综合征患者的临床症状,有效优化激素及神经递质水平,且安全性较高。

Objective To discuss the effect of Yangxin Dingji Capsules on clinical symptoms, related hormone and neurotransmitter in patients with perimenopausal syndrome. Methods From November 2014 to July 2016, 104 patients with perimenopausal syndrome treated in the Third Hospital of Shijiazhuang City were divided into control group and study group by random number table, with 52 cases in each group. Patients in control group were treated with Nilestriol, patients in the study group were treated with Yangxin Ding Ji Capsules and Nilestriol. Treatment lasts for 4 weeks. Before and after treatment, clinical effects were compared between two groups. Kupper-man score, menopause rating scale（MRS）, self-rating depression scale（SDS）, and serum estradiol（E2）, follicle-stimulating hormone（FSH）, luteinizing hormone（LH）, 5-hydroxytryptamine（5-HT）, norepinephrine（NE） and dopamine（DA） levels of the patients in two groups were measured. Adverse reactions were recorded in two groups. Results The total effective rate in study group was90.38%, which was significantly higher than those in control group（P〈0.05）. Compared with before treatment, the Kupper-man, MRS, SDS scores of the two groups were significantly lower after treatment, and the study group was significantly lower than that in control group（P〈0.01）; the level of E2 was significantly higher, levels of FSH and LH were significantly decreased, and the study group improved more significantly（P〈0.01）; the levels of 5-HT, NE and DA increased significantly, and that in study group was significantly higher than in control group（P〈0.01）. Conclusion Yangxin Dingji Capsules can significantly improve the clinical symptoms, hormone and neurotransmitter levels of patients with perimenopausal syndrome and high security.