角音干预对肝火亢盛型自发性高血压大鼠宏观表征及易激惹程度的影响

Effects of Jue Tone Music on Macroscopic Characterization and Irritability of Hypertensive Rats with Liver-fire Hyperactivity Syndrome

目的:观察中医五行音乐(角音)对肝火亢盛型自发性高血压大鼠(SHR)宏观表征及易激惹程度的影响,为进一步探讨角音降低高血压肝火亢盛证的血压、改善临床症状及作用机制的研究提供参考。方法:将20只SHR大鼠随机分为角音组(实验组)和对照组,每组10只,实验组给予连续角音干预(4周),对照组不予处理,每周动态采集宏观表征指标,干预前后对宏观表征进行对照观察和比较易激惹程度评分。结果:经过四周的角音干预,与对照组比较,角音组一般状态和尾部的评分显著高于对照组,两者比较有统计学意义(P<0.05),但角音组被毛的评分和对照组比较,差异无统计学意义(P>0.05);角音组和对照组易激惹程度评分比较,差异有统计学意义(P<0.05)。结论:连续角音干预对高血压肝火亢盛证大鼠的宏观表征及易激惹程度评分具有显著的影响。

Objective： To observe the effects of five elements in music （jue tone） of Traditional Chinese Medicine on macroscopic characterization and irritability of hypertensive rats with liver-fire hyperactivity. Methods： A total of 20 spontaneously hypertensive rats （SHR） were randomly divided into jue tone （experimental） group and control group,with 10 rats in each group.The experimental group was given jue tone intervention for 4 weeks,and control group was not treated.Weekly dynamic macro indicators were collected,and the macroscopic characterization before and after the intervention were observed.The irritability was compared and evaluated. Results： After 4 weeks′ intervention by jue tone,compared with control group,the general status and tail score of rats in experimental group were significantly higher,and there was significant differences between the 2 groups （ P 〈0.05）.There was significant difference in evaluation of irritability between experimental group and control group. Conclusion： Jue tone has significant effects on the macroscopic characterization and evaluation of irritability of SHR rats with liver-hypertension syndrome.