八珍汤加减辅助化疗治疗晚期非小细胞肺癌的临床疗效及对化疗不良反应的影响研究

Study on the Clinical Efficacy of Modified Bazhen Decoction with Adjuvant Therapy of Chemotherapy on Advanced Non-Small Cell Lung Cancer and its Toxic and Side Effects on Chemotherapy

目的:探讨八珍汤加减辅助化疗治疗晚期非小细胞肺癌的临床疗效及对化疗不良反应的影响。方法:选取2014年9月至2016年12月海军总医院收治的晚期非小细胞肺癌患者154例,按随机数字表法分为对照组和观察组,每组77例。对照组予以GP化疗方案治疗,观察组予以GP化疗方案联合八珍汤加减治疗,对2组间血细胞水平、外周血T淋巴细胞水平、生命质量评分进行观察并记录,同时对其临床疗效及不良反应发生率进行比较。结果:观察组总有效率(51.95%)显著高于对照组总有效率(35.07%)(P<0.05);与对照组比较,观察组治疗后血清红细胞(RBC)、白细胞(WBC)、血小板(PLT)水平较高,治疗后外周血CD3+、CD4+T淋巴细胞及CD4+/CD8+水平较高,治疗后FACT-L量表各项内容评分及总分较高,差异有统计学意义(P<0.05);2组患者发生的不良反应主要有胃肠道反应、骨髓抑制、肝功能异常、肾功能损伤、周围神经毒性,观察组各不良反应发生率低于对照组(P<0.05)。结论:八珍汤加减辅助化疗治疗晚期非小细胞肺癌的临床疗效确切,能明显减轻骨髓抑制,改善患者免疫功能及生命质量,减少化疗引起的各种不良反应。

Objective： To investigate the clinical efficacy of Modified Bazhen Decoction with adjuvant therapy of chemotherapy on advanced non-small cell lung cancer and its toxic and side effects on chemotherapy. Methods： A total of 154 patients with advanced non-small cell lung cancer treated in Department of Internal Medicine in Navy General Hospital from September 2014 to December 2016 were selected and divided into control group and observation group according to random number table method,with 77 patients in each group.The control group was treated with GP chemotherapy regimen,and the patients in the experiment group were given Modified Bazhen Decoction on the basis of the same treatment of control group.The level of blood cells,the levels of T lymphocyte in peripheral blood,the quality of life score in both group after the treatment were observed and recorded,and the clinical effect and the incidences of adverse reaction were compared. Results： The effective rate of the experiment group （51.95%） was significantly higher than that of the control group （35.07%） （ P 〈0.05）.After treatment,compared with the control group,the serum levels of red blood cell （RBC）,white blood cell （WBC） and platelet （PLT） increased in the observation group,the peripheral blood CD3＋、CD4 ＋ T lymphocytes and CD4 ＋/ CD8 ＋ levels were increased,and the contents of the FACT-L scale score and the total score were increased （ P 〈0.05）.The adverse reactions of patients in both groups mainly consist gastrointestinal reactions,bone marrow suppression,abnormal liver function,renal function damage,peripheral neurotoxicity,and the incidence of adverse reactions of the experiment group was lower than the control group （ P 〈0.05）. Conclusion： The Modified Bazhen Decoction with adjuvant therapy of chemotherapy in the treatment of advanced non-small cell lung cancer has curative effects.It can significantly reduce bone marrow suppression,improve immune function and quality of life of the patients,and reduce the toxic and side effects caused by chemotherapy.