用复杂网络分析史大卓教授治疗介入后冠心病用药规律

Complex Network Analysis of the Characteristics and Principles of Dialectical Medication and Treatment by Professor Shi Dazhuo in Coronary Heart Disease after Percutaneous Transluminal Coronary Intervention

目的:采用复杂网络挖掘技术分析史大卓教授辨治介入后冠心病的用药规律。方法:利用冠心病中医临床科研信息共享平台收集史大卓教授诊疗介入后冠心病的证候、中药信息,采用复杂网络挖掘技术分析史大卓教授治疗介入后冠心病的用药规律。以中药、证候、功效作为网络节点,构建中药-中药、证候-中药、功效-功效关系的复杂网络结构图。结果:以中药-中药为节点进行复杂网络分析显示,主要中药节点为丹参、生黄芪、川芎、莪术、赤芍、黄连、三七粉、金银花;以证候-中药为节点进行复杂网络分析显示,血瘀对应的主要中药节点是赤芍、丹参、莪术、川芎、红花、三七粉,气虚对应的主要中药节点是生黄芪、党参、西洋参,痰浊对应的主要中药节点是瓜蒌、薤白、半夏、陈皮、茯苓,热毒对应的主要中药节点是黄连、金银花、黄芩;以功效-功效为节点进行复杂网络分析显示,中药功效主要节点是益气、活血、化痰、解毒、安神。结论:史大卓教授善于应用益气活血解毒类中药治疗介入后冠心病,核心组方是丹参、生黄芪、川芎、莪术、赤芍、黄连、三七粉、金银花。

Objective： To analyze the characteristics and principles of syndrome differentiation treatment by Professor Shi Dazhuo in coronary heart disease （CHD） after percutaneous transluminal coronary intervention （PCI） with complex network analysis method. Methods： The syndromes and TCM information of CHD after PCI by Professor Shi through TCM clinical information platform of CHD were collected,and the network node which includes Chinese herbs,syndromes and efficacy was used to build the complex network structure of Chinese herbs-Chinese herbs,syndrome-Chinese herbs and efficacy-efficacy. Results： The complicated network analysis of Chinese herbs-Chinese herbs showed that the main Chinese herb node including Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari,Rhizoma Ligustici Chuanxiong,Rhizoma Curcumae,Radix Paeoniae Rubra,Rhizoma Coptidis,Radix Notoginseng,Flos Lonicerae.The complicated network analysis of syndrome-Chinese herbs showed that the main Chinese herb nodes corresponding to blood stasis were Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae,Rhizoma Curcumae,Rhizoma Ligustici Chuanxiong,Flos Carthami,and Radix Notoginseng.The main Chinese herb nodes corresponding to qi deficiency were Radix Astragali seu Hedysari,Radix Codonopsis,Radix Panacis Quinquefolii.The main Chinese herb nodes corresponding to phlegm were Fructus Trichosanthis,Bulbus Allii Macrostemonis,Rhizoma Pinelliae,Pericarpium Cirri Reticulatae,Poria.The main Chinese herb nodes corresponding to pyretic toxicity were Rhizoma Coptidis,Flos Lonicerae and Radix Astragali seu Hedysari.The analysis of complex network of efficacy-efficacy showed that the main efficacy node contained activating blood circulation,clean heat,stopping pain and calm nerves. Conclusion： Professor Shi is likely to apply benefiting qi for activating blood circulation and detoxifying medicine to treat patients with CHD after PCI.The key materials in his prescription Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari,Rhizoma Ligustici Chuanxiong,Rhizoma Curcumae,Radix Paeoniae Rubra,Rhizoma Coptidis,Radix Notoginseng,Flos Lonicerae..