基于多维宏观量化方法的左归丸及左归饮的组方规律

Discussion on the Composition Rules of Zuogui Pill and Zuogui Decoction Based on the Method of Multi-dimensional Macroscopic Quantification

目的:分析左归丸、左归饮的组方规律并比较二者的差别。方法:选取四气五味及归经指数,对中药剂量进行标准化处理,即计算相对剂量;对相对剂量与四气五味及归经指数进行加权处理,得到四气五味及归经作用度。结果:四气量化:左归丸温性药作用度为210,占22.91%、微温性药作用度为62.4,占77.09%,无偏寒性药;左归饮:均为微温性药,作用度为62.4,占100%。五味量化:左归丸:甘味作用度为444.4,占52.14%、咸味作用度为192,占22.52%、酸味作用度为108,占12.67%;左归饮:甘味作用度为184.9,占62.70%、酸味作用度为60,占20.35%、涩味作用度为48,占16.28%。归经量化:左归丸:肝经作用度为528,占48.52%、肾经作用度为512.4,占47.11%;左归饮:肝经作用度为216,占46.24%、肾经作用度为171.64,占38.03%。结论:左归丸偏为温性,较为平和,五味以甘、咸、酸为主,主入肝、肾经;左归饮同为温性平和之品,五味以甘、酸、涩为主,主入肝、肾经。左归丸比较于左归饮在滋阴之中又加以血肉有情及助阳之品,补力更峻,余无明显差别。

Objective： To analyze the composition rules of Zuogui Pill and Zuogui Decoction by using the method of multi-dimensional macroscopic quantification. Methods： The index of four properties and five flavors and channel tropism was set,and dosages of the traditional Chinese medicine were standardized.The relative dosage was calculated.Relative dosage,four properties and five flavors and channel tropism were weighted to obtain the potency of four properties and five flavors and channel tropism. Results： 1）Quantification of four properties：Zuogui Pill：the warm potency was 210,occupying 22.91%,while the light warm potency was 62.4,occupying 77.09%.There was no cold potency.Zuogui Decoction：all were warm potency and the potency degree was 62.4,occupying 100%.2）Quantification of five flavors：Zuogui Pill：sweet potency was 444.4,occupying 52.14%.Salty potency was 192,occupying 22.52%.Sour potency was 108,occupying 12.67%.Zuogui Decoction：sweet potency was 184.9,occupying 62.70%.Sour potency was 60,occupying 20.35%.Astringent potency was 48,occupying 16.28%.3）Quantification of channel tropism：Zuogui Pill：Liver channel potency was 528,occupying 48.52%.Kidney channel potency was 512.4,occupying 47.11%; Zuogui decoction：Liver channel potency was 216,occupying 46.24%.Kidney channel potency was 171.64,occupying by38.03%. Conclusion： Zuogui Pill is inclined to be warm and mild.The five flavors are mainly sweet,salty and sour.It is mainly in liver and kidney channels.Zuogui decoction is also inclined to be warm and mild.The five flavors are mainly sweet,salty and astringent.It is also mainly in liver and kidney channels.Compared with Zuogui decoction,Zuogui Pill is more powerful but friendly in blood and flesh.The remaining has no significant difference.