脑功能成像技术在针灸治疗肠易激综合征中的应用

Application of Functional Magnetic Resonance Imaging in Acupuncture and Moxibustion Treatment of Irritable Bowel Syndrome

肠易激综合征(IBS)是一种慢性功能性肠病并常伴有焦虑、抑郁等心理障碍,其发病率高、症状易反复,严重影响患者的生活和工作。针灸治疗IBS的临床疗效肯定,但其作用机制尚不明确。随着神经影像学技术的发展,越来越多的学者应用该技术研究IBS患者脑功能活动的变化,发现IBS多个脑区活动存在异常,如脑岛、前扣带回、前额叶等与IBS内脏感觉与情绪调节密切相关的脑区,而针灸治疗对相应脑区的功能活动具有一定的调节作用,这可能为我们了解针灸治疗IBS的作用机制提供了客观的依据。因此,本文就应用脑功能成像技术在针灸治疗对IBS脑功能活动的影响及其可能的作用机制作一综述。

Irritable bowel syndrome （IBS） is a chronic functional gastrointestinal disease and often accompanied by psychological disorders such as anxiety,depression.It has high morbidity rate and recurrence rate,which seriously affect the patients′ work and life.The curative effect of acupuncture therapy on IBS patients is significant but the mechanism of action is still undefined.With the development of neuro imaging technology,more and more scholars study the brain activity of IBS patients with the application of neuro imaging techniques.They found abnormal activities in multiple brain regions of IBS patients,such as the insula,anterior cingulate cortex,the prefrontal cortex and other brain regions which are closely related to the regulation of sensation and emotion in IBS.And acupuncture treatment had certain regulating effect on the functional activities of the corresponding brain regions,which may provide a visual basis for understanding the mechanism of acupuncture on IBS.Hence,this paper reviewed the effect and mechanism of acupuncture treatment on the brain activities of IBS patients with the application of functional magnetic resonance imaging technology.