深圳市宝安区新生儿凝血功能指标变化的研究

Study of changes of coagulation function indicators in neonates in Bao ′an District, Shenzhen City

目的探讨深圳市宝安区新生儿凝血功能5项参考区间及新生儿凝血功能的变化规律。方法选取2017年6月～2018年1月我院产科收治的出生的250例新生儿作为研究对象,根据新生儿妊娠周是否达到37周将新生儿分为足月组和早产组,每组各125例。比较足月组、早产组新生儿出生后1 d内的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)及血小板计数(PLT),并比较不同日龄(出生后1～<3、3～<7、7～<14、14～<21 d)新生儿的上述各指标水平。结果早产组新生儿出生后的PT、APTT、TT明显高于足月组,差异有统计学意义(P<0.05),Fib、PLT明显低于足月组,差异有统计学意义(P<0.05);新生儿出生后14～<21 d的PT、APTT、TT均明显低于出生1～<3 d,差异有统计学意义(P<0.05);新生儿出生后14～<21 d的Fib、PLT均明显高于出生1～<3 d,差异有统计学意义(P<0.05)。结论本地区新生儿凝血功能指标的分布具有其自身的特点,早产儿中PT、APTT、TT时间与大于足月儿相比均较高,而FIB、PLT均较低。

Objective To explore five reference intervals and the change rule of coagulation function in neonates in Bao＇an District, Shenzhen City. Methods A total of 250 neonates born in our Department of Obstetrics from June 2017 to January 2018 were selected as the subjects. According to whether the gestational cycle reaching 37 weeks, the neonates were divided into full-term group and preterm group, with 125 cases in each group. The prothrombin time （PT）, activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （Fib） level and platelet count （PLT） within 1 day after birth in the full-term group and the preterm group were compared, as well as the levels of the above-mentioned indicators of newborns at different time such as 1-〈3, 3-〈7, 7-〈14 and 14-〈21 days. Results The postpartum PT, APTT and TT in the preterm group were significantly higher than those in the full-term group （P〈0.05）, while the levels of FIB and PLT were significantly lower than those in the full-term group （P〈0.05）. The levels of PT, APTT and TT of neonates on 14-〈21 days after birth were significantly lower than those on 1-〈3 days （P〈0.05）, while the levels of FIB and PLT of neonates on 14-〈21 days after birth were significantly higher than those on 1-〈3 days （P〈0.05）. Conclusion The distribution of neonatal coagulation function indicators in this region has its own character- istics.The levels of PT, APTT and TT of preterm infants are longer than those of full-term infants, while the levels of FIB and PLT are lower.