摘要
A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide (f-Amphamide) ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results (up to 〉99% conversion, 〉99% ee and TON up to 200 000). DFT calculations suggest an activating model involving an alkali cation Li.
A series of novel and easily accessed ferrocene-based amino-phosphine-sulfonamide (f-Amphamide) ligands have been developed and ap- plied in Ir-catalyzed asymmetric hydrogenation of aryl ketones, affording the corresponding chiral secondary alcohols with excellent results (up to 〉99% conversion, 〉99% ee and TON up to 200 000). DFT calculations suggest an activating model involving an alkali cation Li.