血清碱性磷酸酶及其与卒中的相关性进展

Progress in serum alkaline phosphatase and its correlation with stroke

碱性磷酸酶(alkaline phosphatase,ALP)作为一种血管钙化调节剂,与动脉粥样硬化、血管稳态及炎症反应等相关。近年有研究表明血清ALP对卒中的发生风险有预测价值,血清ALP与卒中后神经功能缺损及不良预后呈正相关;且血清ALP水平越高,发生卒中后死亡风险的可能性越大;另外,血清ALP对缺血性卒中后症状性出血转化及脑微出血有预测价值。

Alkaline phosphatase（ALP）, as a vascular calcification regulator, is related to atherosclerosis, vascular homeostasis and inflammatory response. In recent years, studies have shown that serum ALP has a predictive value for the risk of stroke. Serum ALP was positively correlated with neurological deficit and poor prognosis after stroke. The higher the serum ALP level, the greater the risk of death after stroke. In addition, serum ALP has a predictive value for symptomatic hemorrhagic transformation and cerebral microbleeds after ischemic stroke.