CRMP2翻译后修饰及相关信号通路的研究进展

Post-translational modification of CRMP2 and the related signaling pathway

脑衰反应调节蛋白2（CRMP2）在发育中及成年后神经系统中均高度表达，参与神经系统的发育以及神经可塑性，与多种神经精神疾病的发生密切相关。CRMP2存在多种翻译后修饰方式，包括磷酸化、氧化、蛋白水解、泛素化等，其中最重要的修饰方式即为磷酸化修饰，CRMP2的磷酸化会影响其与细胞骨架蛋白以及其他下游分子的结合，影响神经系统的多种功能。现就CRMP2翻译后修饰形式及相关信号通路作一综述。

CRMP2 is highly expressed in the developing and adult nervous systems and regulates skeletal dynamics by interacting with cytoskeletal proteins. It plays an important role in the development of nervous system and neuroplasticity, and is closely related to the occurrence of many neuropsychiatric diseases. There are many post-translational modifications （PTMs）, including phosphorylation, oxidation, proteolysis and ubiquitination. Among them, the most important modification is phosphorylation. PhosphotTlation of CRMP2 can affect its binding to the cytoskeletal proteins and other downstream molecules, then affect many functions of the nervous system. This article reviews the posttranslational modifications and related signaling pathways.