美沙拉嗪联合双歧三联活菌对溃疡性结肠炎的疗效

Effect of mesalazine combined with bifidobacterium on ulcerative colitis

目的观察美沙拉嗪联合双歧三联活菌对溃疡性结肠炎患者的疗效及肿瘤坏死因子-α(TNF-α)、白细胞介素-10(IL-10)水平的影响。方法将100例溃疡性结肠炎患者采用随机数字表法分为观察组与对照组,每组50例。对照组采用美沙拉嗪治疗,观察组则在对照组的基础上加用双歧三联活菌治疗。对比两组患者临床疗效,治疗前后血清TNF-α、IL-10、丙二醛(MDA)、超氧化物歧化酶(SOD)水平以及不良反应发生情况。结果观察组患者治疗总有效率为92.00%(46/50),显著高于对照组的76.00%(38/50),差异有统计学意义(P<0.05)。治疗后观察组血清TNF-α、MDA水平显著低于对照组,而IL-10、SOD水平显著高于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率显著低于对照组(4.00%vs. 16.00%),差异有统计学意义(P<0.05)。结论美沙拉嗪联合双歧三联活菌治疗溃疡性结肠炎的临床疗效显著,安全性较好,值得临床推广应用。

Objective To study the effect of the mesalazine combined with bifidu- triplets on the curative effect of the patients with ulcerative colitis and on the levels of tumor necrosis factor-α （TNF-ct）and interleukin-10 （IL-10）. Methods 100 patients with ulcerative colitis were selected, and were divided into observation group and control group according to the random number table method. The patients in the control group were treated with mesalazine, and the observation group was treated with mesalazine combined with bifidosan living bacteria. The clinical efficacy of the two groups were compared, and the serum TNF-a, IL-10, MDA and SOD levels and adverse reactions were also compared. Results The total effective rate of treatment in the observation group was 92.00% （46/50） , significantly higher than the control group of 76.00% （38/50） （P〈O.05）. In the observation group after treatment, serum TNF-ct and SOD levels were significantly lower than those in the control group, and IL-10 and MDA levels were significantly higher than those of control group （P〈0.05）. The incidence of adverse reactions in the observation group was significantly lower than that of the control group （P〈O.05）. Conclusion The clinical efficacy of mesalazine combined with trigeminus in the treatment of ulcerative colitis was significant, safe, and it was worthy of clinical application.