摘要
天然产物全合成是有机化学的重要研究方向之一,具有复杂结构和重要生理活性的天然产物及其衍生物也是药物研发的重要来源.主要介绍利用化学合成与生物合成结合的策略,实现复杂天然产物的全合成及规模制备.主要内容包括青蒿素,Spinosyn A,Myceliothernophin E和Equisetin的化学与生物合成研究.
Total synthesis of natural products is one of the most important field in organic chemistry. Natural products and derivatives, containing complex structures and potential biological activities, are also indispensable sources of drug discovery.The total synthesis of natural products through the combination of chemical synthesis and biosynthesis strategies is reviewed.The main content includes the chemical and biosynthetic studies of artemisinin, spinosyn A, myceliothernophin E and equisetin.
作者
李晓军
张万斌
高栓虎
Li Xiaojun1,Zhang Wanbin3,Gao Shuanhu1,2(a Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, Shanghai 200062;b Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062;c School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 20024)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第9期2185-2185,2186-2198,共14页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21772044)
上海市优秀学术/技术带头人计划(No.18XD1401500)
中央高校基本科研业务费资助项目~~
关键词
天然产物全合成
化学合成
生物合成
total synthesis of natural products
chemical synthesis
biosynthesis
