感染性胰腺坏死的病原学研究进展

Research progress of pathogenesis of infected pancreatic necrosis

感染性胰腺坏死(IPN)是急性胰腺炎的严重并发症,也是患者死亡的主要原因。微创行胰腺坏死组织清除配合抗菌素是目前IPN治疗的主要方式。IPN多为院内获得性感染,菌谱复杂,多重耐药菌常见,抗菌素选择困难。目前,针对IPN患者病原菌及耐药性的临床资料有限,所以了解其发病的危险因素,细菌谱,耐药性及相关预后可以对患者进行更佳的诊治。

Infected pancreatic necrosis （IPN） is a serious complication of acute pancreatitis and it is also a leading cause of death. Minimally invasive debridement of the necrotic pancreatic tissue combined with antibiotics is currently the main treatment method for IPN. IPN is mostly involving hospital-acquired infections, with complex spectrum, frequent multidrug-resistant bacteria, and difficult choice of antibiotics. At present, the clinical data on the pathogens and drug resistance of IPN patients are limited, so understanding the risk factors for its occurrence, bacterial spectrum, drug resistance and related prognosis can provide better diagnosis and treatment for these patients.