温补脾肾方联合左旋甲状腺素治疗甲状腺功能减退症对血液流变学及血脂水平的影响

Effect of Warming Spleen and Kidney Recipe Combined with Levothyroxine on Hemorheology and Blood Lipid Level in Patients with Hypothyroidism

目的：探讨温补脾肾方联合左旋甲状腺素治疗甲状腺功能减退症的临床疗效,并分析其对血液流变学及血脂水平的影响。方法：选取2016年7月—2017年9月本院收治的甲状腺功能减退症患者101例为研究对象,随机分为研究组51例与对照组50例,对照组患者给予左旋甲状腺素片治疗,研究组患者给予温补脾肾方联合左旋甲状腺素片治疗,对比两组患者临床疗效、治疗前后血液流变学相关指标水平、血脂水平、甲状腺激素水平,并对比治疗前后中医证候积分。结果：研究组患者的总有效率为92.16%,明显高于对照组的总有效率78.00%（P〈0.05）;治疗后,研究组与对照组患者的血红蛋白水平、FT3、FT4水平明显较治疗前升高,血浆黏度、纤维蛋白原、红细胞变性指数、TG、TC水平、TSH水平较治疗前降低（P〈0.05）,且治疗后研究组患者的血红蛋白水平、FT3、FT4水平明显高于对照组,血浆黏度、纤维蛋白原、红细胞变性指数、TG、TC水平、TSH水平明显低于对照组（P〈0.05）;治疗后,研究组与对照组患者面浮肢肿、畏寒肢冷、神疲乏力、纳呆腹胀证候积分明显较治疗前降低（P〈0.05）,且研究组患者面浮肢肿、畏寒肢冷、神疲乏力、纳呆腹胀证候积分明显低于对照组（P〈0.05）。结论：温补脾肾方联合左旋甲状腺素治疗甲状腺功能减退症临床疗效显著,且能有效改善患者血液流变学、血脂水平及甲状腺功能,值得临床推广。

Objective： To explore the clinical effect of warming spleen and kidney method combined with levothyroxine in the treatment of hypothyroidism and analyze its effect on blood rheology and blood lipid level. Methods： A total of 101 cases of hypothyroidism in our hospital from July 2016-December 2017 were selected as the subjects. The patients were randomly divided into51 cases in the study group and 50 cases in the control group. The control group was treated with levothyroxine tablets. The patients in the study group were given Warming Spleen and Kidney Formula combined with levothyroxine tablets. The bed efficacy,hemorheology related indexes,blood lipid level and thyroid hormone level before and after treatment were compared,and the TCM syndrome scores before and after treatment were compared. Results： The total effective rate of the patients in the study group was92. 16%,significantly higher than the control group＇s 78%（P〈0. 05）. After treatment,the levels of hemoglobin,FT3 and FT4 in the study group and the control group were significantly higher than those before treatment. The plasma viscosity,fibrinogen,denatured red blood cell index,TG,TC level and TSH level were more than those before treatment. After treatment,the levels of hemoglobin,FT3 and FT4 of the patients in the study group were significantly higher than those in the control group. The plasma viscosity,fibrinogen,erythrocyte degeneration index,TG,TC level and TSH level were significantly lower than those of the control group（P〈0. 05）. After treatment,the study group and the control group＇s floating limbs swollen,cold limbs cold were lower than those before treatment（P〈0. 05）. The score of fatigue and abdominal distention was significantly lower than that before treatment（P〈0. 05） and the score of floating limb swelling,cold limb cold,fatigue and abdominal distention in the study group was significantly lower than that of the control group（P〈0. 05）. Conclusion： The clinical effect of Warming Spleen and Kidney Prescription and levothyroxine in the treatment of hypothyroidism is significant,and it can effectively improve the blood rheology,blood lipid level and thyroid function,which is worthy of clinical promotion.