趋磁细菌及磁小体的生物医学应用研究进展

Research Progress on Biomedical Applications of Magnetotactic Bacteria and the Biosynthetic Magnetosomes

近年来,趋磁细菌及其生物自身合成的磁小体由于良好的生物安全性逐渐被人们所认识,并被用于生物工程和医学应用研究。与人工化学合成磁性纳米颗粒相比,从趋磁细菌中提取的磁小体具有生物膜包被、生物相容性高、粒径均一及磁性高等优势。趋磁细菌因磁小体在其胞内呈链状排列,具有沿磁场方向泳动的能力,也被应用于各种应用研究。因此,综述了趋磁细菌及磁小体特性,并就最近的研究进展重点综述趋磁细菌和磁小体在生物工程及医学应用等领域的最新研究进展。

In recent years, magnetotactic bacteria and their biosynthetic magnetosomes have been recognized and have been used in biological and medical applications by people because of their good biosafety.Compared with synthetic magnetic nanoparticles, magnetosomes extracted from magnetotactic bacteria have biomembrane coated,high biocompatibility,uniform particle size and high magnetic. Because magnetotactic bacteria swam along magnetic field,they are also applied in biomedical applications. The characterization of magnetotactic bacterium and magnetosome are first descripted,then reviewed their apllications in biomedical in latest research progress.