血清PCT与C反应蛋白检测对小儿发热性疾病的诊断价值研究

Diagnostic Value Research of Serum PCT and CRP in Children with Febrile Diseases

目的探讨血清降钙素原(PCT)与C反应蛋白(CRP)检测对小儿发热性疾病的诊断价值,为提高小儿发热性疾病诊治水平提供依据。方法收集2016年10月~2018年2月我院儿科收治的76例发热性疾病患儿的一般资料、临床以及随访资料作为研究对象,根据出院诊断分为细菌感染组和非细菌感染组,同时收集同期健康体检儿童38例为对照组,检测两组患儿血清PCT及CRP水平,并与对照组患儿进行统计分析。结果 3组外周血中CRP和PCT表达水平比较差异著性(F=54.840,P<0.001;F=32.05,P<0.001);两两比较:细菌感染组外周血中CRP和PCT表达水平均明显高于非细菌感染组和对照组,数据差异均具有统计学意义(t=4.976,P<0.001;t=6.155,P<0.001;t=6.454,P<0.001);非细菌感染组外周血中CRP和PCT表达水平均高于对照组,但差异无显著性(t=0.176,P=0.817;t=0.398,P=0.617);根据ROC曲线结果显示:外周血中CRP和PCT在ROC曲线下的面积均>0.8;CRP和PCT这2个指标联合后对发热性疾病的预测价值,敏感度为78.11%,特异度为100.00%。结论血清降钙素原及C反应蛋白可作为小儿发热细菌感染的特异性指标,值得临床推广应用。

Objective This study aimed to investigate the diagnostic value of serum PCT and CRP in children with febrile diseases,in order to provide the basis for the improvement of treatment level.Methods A total of 76 cases of febrile diseases in our hospital from Oct 2016 to Feb 2018 with General,clinical and follow-up data were selected,and divided into the bacterial infection group and the non bacterial infection group,38 cases of healthy children were seen as the control group.The serum PCT and CRP level of the two groups were detected and analyzed.Results There was statistic significance in the serum PCT and CRP expression levels in the three groups（F=54.840,P〈0.001;F=32.05,P〈0.001）;serum PCT and CRP expression levels in the bacterial infection group were significantly higher than those in the non bacterial infection group through pairwise comparison,the difference was statistic significant（t=4.976,P〈0.001;t=6.155,P〈0.001;t=6.454,P〈0.001）;serum PCT and CRP expression levels in the non bacterial infection group were significantly higher than those in the control group,the difference was not statistic significant（t=0.176,P=0.817;t=0.398,P=0.617）;ROC showed that,the areas of PCT and CRP in ROC were all〉0.8;the sensitiveness,specificity of PCT and CRP to febrile diseases were 78.11%,100.00%.Conclusion Serum PCT and CRP can be seen as the specific indexes in children with febrile diseases,it is worthy of wide application.