白细胞计数、C反应蛋白和中性粒细胞淋巴细胞比值与房颤患者心脏结构变化的相关性分析

Correlation of White Blood Cell Count,C Reactive Protein and Neutrophil Lymphocyte Ratio with Cardiac Structural Changes in Patients with Atrial Fibrillation

目的探讨白细胞计数(WBC)、C反应蛋白(CRP)和中性粒细胞淋巴细胞比值(NLR)与房颤患者心脏结构变化的相关性。方法选取2016年1月至2017年1月我院收治的108例房颤患者(观察组)和60例同期于我院体检正常者(对照组)作为研究对象,采取回顾性分析法分析所有纳入研究者的临床资料,记录所有纳入研究者其性别、年龄、体质量指数等一般临床资料,分析WBC、CRP和NLR水平与患者心脏结构指标的相关性。结果观察组CRP、NLR、心脏结构指标均高于对照组(P<0.05)。Spearman等级相关分析显示:WBC与心脏结构指标呈正相关,CRP与心脏结构指标呈负相关;NLR与心脏指标中的LVPWT、LVD呈正相关而与其他心脏结构指标呈负相关。结论 WBC、CRP及NLR与房颤患者心脏结构指标呈相关性,为房颤的危险因素,可作为临床上评估患者发生房颤的重要参考指标。

Objective This study aimed to investigate the correlation between white blood cell count（WBC）,C reactive protein（CRP）and neutrophil lymphocyte ratio（NLR）and cardiac structural changes in patients with atrial fibrillation.Methods A total of 108 patients with atrial fibrillation（observation group）and 60 cases with normal physical examination in our hospital（control group）from January 2016 to January 2017 were selected retrospectively as the research objects.The gender,age,body mass index and other clinical data was recorded,and the correlation between WBC,CRP and NLR and cardiac structural parameters was analyzed.Results The level of CRP and NLR in the observation group were higher than those in the control group,and the cardiac structural parameters of the observation group were greater than those of the control group（P〈0.05）.Spearman rank correlation analysis showed that there was a positive correlation between WBC and the cardiac structural parameters,CRP been negatively correlated with those parameters.NLR was positively correlated with LVPWT and LVD in cardiac structural parameters,while negatively correlated with other parameters.Conclusion There was significant correlation between WBC,CRP and NLR and cardiac structural parameters in patients with atrial fibrillation,which may be risk factors for atrial fibrillation and be used as important indicators of clinical assessment.