骨松健骨丸治疗绝经后骨质疏松症的临床疗效观察

Clinical effects of gusu jiangu pills on post-menopausal osteoporosis

目的观察骨松健骨丸治疗绝经后骨质疏松症(PMOP)的临床疗效。方法 78例住院患者按住院先后顺序随机地分为对照组和治疗组,两组同时在医生指导下进行适当运动锻炼,对照组口服阿伦磷酸钠及碳酸钙D3片,治疗组口服骨松健骨丸及碳酸钙D3片。治疗后检测骨痛评分[视觉模拟评分(VAS评分)]、骨密度平均值(T值)、骨代谢指标[抗酒石酸酸性磷酸酶-5b(TRACP-5b)、骨钙素(BGP)]水平。结果经过治疗3个月后,治疗组总有效率为84.21%,对照组为81.08%,两组总有效率比较差异无统计学意义(P>0.05)。治疗后3个月治疗组与对照组VAS评分、T值、TRACP-5b、BGP水平比较,差异有统计学意义(P<0.05)。两组在治疗后3个月分别与治疗前VAS评分、T值、TRACP-5b、BGP水平比较,差异有统计学意义(P<0.05)。结论骨松健骨丸能改善PMOP患者的临床症状,提高患者骨密度其效果和阿伦磷酸钠效果一致。

Objective To observe the clinical effects of gusong jiangu pills on post-menopausal osteoporosis.Methods A total of 78 inpatients were randomized into a control group and a treatment group according to the visit sequence. The proper physical exercise was provided under the guidance in the two groups. In the control group,alendronate and calcium carbonate D3 tablets were taken orally. In the treatment group,gusong jiangu pills and calcium carbonate D3 tablets were taken orally. After treatment,VAS score,the mean value of bone density（T value） and bone metabolic indexes（TRACP-5 b and BGP） were determined after treatment. Results In 3 months of treatment,the total effective rate was84. 21% in the treatment group and was 81. 08% in the control group,without significant differences（P〈0. 05）. In 3 months of treatment,VAS score,T value and the levels of TRACP-5 b and BGP in the treatment group were different significantly as compared with the control group（P〈0. 05）. The results of those indexes were different significantly as compared with those before treatment in the two groups（P〈0. 05）. Conclusion Gusong jiangu pills relieve the clinical symptoms of post-menopausal osteoporosis and improve the bone density. The effects are same as alendronate. This herbal medicine is safe and effective and deserves to be promoted in clinical practice.