大肠癌高危人群大肠癌检出率比较研究

The study on the detection rate of colorectal cancer in the high-risk group of colorectal cancer

目的比较大肠癌高危人群的大肠癌检出率,探讨各危险因素在大肠癌发病中所占的权重。方法计算不同高危人群(大肠癌高危人群、既往有大肠腺瘤性息肉史人群、慢性阑尾炎史人群、既往大肠癌病史人群、慢性胆囊炎、胆囊结石/胆囊切除术人群、一级亲属患大肠癌患者、糖尿病人群、合并其他部位恶性肿瘤人群、炎症性肠病人群)的大肠癌检出率,并依据性别、年龄、病程实施大肠癌检出率比较。结果大肠癌高危人群中,患糖尿病者的大肠癌检出率(13.6%)>一级亲属患大肠癌者(10.2%)>合并其他部位恶性肿瘤者(8.7%)>既往有大肠癌病史者(7.9%)>患慢性阑尾炎者(5.7%)>患慢性胆囊炎者(4.6%)>患炎症性肠病者(4.0%)>既往有大肠腺瘤性息肉者(1.2%);不同性别、年龄及病程大肠腺瘤性息肉史人群的大肠癌检出率差异无统计学意义;年龄越大、病程越长的有慢性阑尾炎病史的人群大肠癌的检出率较高,具有统计学意义;既往有大肠癌病史的男性患者大肠癌检出率较高,具有统计学意义;不同性别、年龄及病程的既往有胆囊疾病史人群的大肠癌检出率差异无统计学意义;不同性别、年龄及病程的一级亲属患大肠肿瘤人群的大肠癌检出率差异无统计学意义;年龄越大(>50岁)的糖尿病人群的大肠癌检出率较高,具有统计学意义;不同性别、年龄及病程的合并其他部位恶性肿瘤的人群的大肠癌检出率差异无统计学意义;不同性别、年龄及病程炎症性肠病人群的大肠癌检出率差异无统计学意义。结论糖尿病史、既往有大肠腺瘤性息肉史者的大肠癌检出率最高;年龄越大(>50岁)的糖尿病患者,既往有大肠癌病史的男性患者,年龄越大、病程越长的有慢性阑尾炎病史患者在大肠癌的发病中所占的比例较高。

Objective To compare the detection rate of colorectal cancer among the high-risk group,and study the weight of different risk factors in the incidence of colorectal cancer. Methods Calculate the detection rate of colorectal cancer among different high-risk groups（ colorectal cancer high-risk groups,the crowd ever had a history of colorectal adenomatous polyp,population had history of chronic appendicitis,patients ever suffer from colorectal cancer, the population ever suffered chronic cholecystitis or gallbladder stone/cholecystectomy,the population whose first-degree relatives suffered colorectal cancer,population with diabetes,the patients with the other kinds of malignant tumor,and patients with inflammatory bowel disease）,and compared the differences of detection rate on the basis of gender,age,course of implementation of colorectal cancer.Results Among the high-risk groups,the detection rate of colorectal cancer ranged as follows： patients with diabetes（ 13. 6%）,population whose first-degree relatives suffered colorectal cancer（ 10. 2%）,patients with the other kinds of malignant tumor（ 8.7%）,patients ever suffer from colorectal cancer（ 7.9%）,population had history of chronic appendicitis（ 5.7%）,population suffer from chronic cholecystitis（ 4. 6%）,patients with inflammatory bowel disease（ 4.0%）,the crowd ever had a history of colorectal adenomatous polyp（ 1. 2%）. In the population ever had a history of colorectal adenomatous polyp,there were no statistically significant difference in the detection rate of colorectal cancer among different genders,ages and course of disease. In the patients with chronic appendicitis,the detection rate of colorectal cancer was higher in patients with older age and longer course of disease. The detection rate of colorectal cancer was higher in men with a history of colorectal cancer. In the population ever suffered from gallbladder disease,there were no statistically significant difference in the detection rate of colorectal cancer in patients with different gender,age and course of disease. In the population whose first-degree relatives suffered colorectal cancer,there were no statistically significant difference in the detection rate of colorectal cancer in patients with different gender,age and course of disease. In the patients with diabetes,the detection rate of colorectal cancer increased as the age increased（ elder than 50 years old）. In the patients with other kinds of malignant tumors and inflammatory bowel disease,there were no significant differences in the detection rate of colorectal cancer among different genders,ages and course of disease. Conclusions Diabetes,previous history of colorectal adenomatous polyps had the highest detection rate of colorectal cancer. The incidence of colorectal cancer was higher in the following populations：elder diabetes（elder than 50 years old）,male population with previous history of colorectal cancer and the population with a history of chronic appendicitis.