杭州地区体检人群尿酸与血脂异常率及相关性分析

The abnormality rate of uric acid and blood lipid in the health examination population in Hangzhou and the relation between them

目的分析杭州市体检人群尿酸与血脂的异常率及相关性。方法回顾性分析2016年1月—2017年12月杭州市某体检中心进行健康体检的42521名杭州地区居民的体检资料。比较血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的检测结果及尿酸(UA)水平。分析尿酸与血脂之间的相关性及异常检出率与年龄、性别的关系。结果尿酸和血脂异常检出率分别为20.7%和48.5%,男性高于女性,且差异具有统计学意义(P<0.05)。尿酸异常率在60岁之前随年龄的增长而增长,并在80岁以后出现第二次峰值。血脂异常率70岁以前随年龄增长呈递增趋势,70岁以后异常率逐渐下降。尿酸与血脂指标中的TC、TG、LDL-C呈正相关,与HDL-C呈负相关。高尿酸组的血脂异常率明显高于尿酸正常组,差异有统计学意义(P<0.05)。结论体检人群的尿酸与血脂异常检出率较高,与年龄、性别关系显著,且尿酸与血脂间确实存在相关性。高血脂和高尿酸都是心脑血管类疾病的危险因素,加强对血脂和尿酸的监控,倡导合理饮食,开展健康宣教,对降低此类疾病的发生有重要意义。

Objective Analyze the prevalence and correlation of uric acid and blood lipid abnormality in examination population in Hangzhou. Methods A retrospective analysis of the physical examination data of 42,521 residents from July 2016 to June 2017 in a physical examination center of Hangzhou. Compare the concentration of total cholesterol（ TC）,triglyceride（ TG）,high-density lipoprotein cholesterol（ HDL-C）,lowdensity lipoprotein cholesterol（ LDL-C）,and blood uric acid. The relationship between uric acid and blood lipids,the correlation between abnormal detection rate and age and sex were analyzed. Results Among the detection population,the abnormal rates of blood lipids and uric acid were 20.7%,48.5% respectively. Compared with females,males had higher rates of abnormal rate,the difference was statistically significant（ P〈0.05）. The level of uric acid was increased with age before 60 years old,and appeared a second peak when age reached 80 years old. The abnormal rate of blood lipids was increased with age before 70 years old,and then it was gradually decreased after 70 years old. Uric acid was positively correlated with TC,TG,and LDL-C,which was negatively correlated with HDL-C. The abnormal rate of blood lipid in high uric acid group was higher than that in normal uric acid group（ P〈0. 05）. Conclusions The abnormal rate of uric acid and blood lipids in the examination population in Hangzhou is high,and significantly correlated with age and sex. And there was a correlation between uric acid and blood lipids. Both abnormalities of uric acid and blood lipids are risk factors of cardiovascular and cerebrovascular diseases. It is of great significance to strengthen the monitoring of blood lipid and uric acid index,advocate rational diet and carry out health education.