醋酸阿托西班治疗先兆早产临床疗效分析

Analysis on clinical effect of atosiban acetate in treatment of threatened premature labor

目的评价醋酸阿托西班在治疗先兆早产中的临床价值。方法回顾性分析2016年11月-2017年12月应用醋酸阿托西班治疗先兆早产的15例患者临床资料,分析醋酸阿托西班治疗先兆早产的宫缩抑制情况、延长孕周、不良反应发生情况及妊娠结局。结果宫缩完全抑制7例,其中1例行紧急宫颈环扎术联合醋酸阿托西班治疗,3例行宫颈托放置术联合醋酸阿托西班治疗;宫缩明显抑制7例,其中1例行紧急宫颈环扎术联合醋酸阿托西班治疗,2例行宫颈托放置术联合醋酸阿托西班治疗;宫缩未能有效抑制1例。仅有1例出现轻微头晕、恶心症状,未出现因严重不良反应停止醋酸阿托西班治疗的情况。足月产2例,早产8例,延长胎龄23日后难免流产1例,规律宫缩难免流产1例,3例患者目前仍在继续妊娠中。结论醋酸阿托西班能有效抑制宫缩、延长孕周,无明显不良反应,妊娠结局良好。

Objective To evaluate the clinical value of atosiban acetate in treatment of threatened premature labor. Methods From November 2016 to December 2017,the clinical data of 15 patients with threatened premature labor treated by atosiban acetate was analyzed.Inhibition of uterine contraction,extension of gestational week,incidence rates of adverse reactions,and pregnancy outcome were analyzed.Results Complete inhibition of uterine contraction was observed in seven patients,including one patient treated by emergency cervical cerclage combined with atosiban acetate and three patients treated by cervical pessary combined with atosiban acetate. Significant inhibition of uterine contraction was observed in seven patients,including one patient treated by emergency cervical cerclage combined with atosiban acetate and two patients treated by cervical pessary combined with atosiban acetate. Inhibition of uterine contraction failed in one patient. Only one patient was found with mild dizziness and nausea,atosiban acetate treatment was not stopped due to serious adverse reactions. Two fullterm infants and 8 premature infants were born. One patient with inevitable abortion after 23 days of prolonged gestational age and one patient with inevitable abortion were found,three patients continued pregnancy. Conclusion Atosiban acetate can effectively inhibit cervical contraction and prolong gestational age,no obvious adverse effect is found,and pregnancy outcome is good.