瑞替普酶联合替罗非班对急性心肌梗死患者的凝血和微循环影响

Effects of raltip and tirofiban on coagulation and microcirculation in patients with acute myocardial infarction

目的:探讨瑞替普酶联合替罗非班治疗对急性心肌梗死患者的凝血和微循环相关指标的影响。方法:将急性心肌梗死患者96例随机分为两组,每组48例。对照组给予瑞替普酶治疗,在此基础上,观察组加用替罗非班治疗,比较两组凝血和微循环相关指标及不良反应。结果:观察组PI、AUC较对照组高,QTd间期较对照组低,差异具有统计学意义(P<0.05)。观察组PT、APTT及TT水平均较对照组高,差异具有统计学意义(P<0.05)。两组不良反应发生率无统计学差异。结论:瑞替普酶联合替罗非班治疗可改善急性心肌梗死患者的凝血和微循环相关指标。

Objective： To investigate the effect of reteplase combined with tirofiban on coagulation and microcirculation in patients with acute myocardial infarction. Methods： 96 patients with acute myocardial infarction were randomly divided into two groups,48 cases in each group. The control group was treated with reteplase,and the observation group was treated with reteplase and tirofiban. The coagulation and microcirculation related indexes and adverse reactions were compared between the two groups. Results：The PI and AUC in the observation group were higher than those in the control group,and the QTd interval was lower than that in the control group（ P〈0. 05）. The levels of PT,APTT and TT in the observation group were higher than those in the control group,and the differences were statistically significant（ P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion： The combination of reteplase and tirofiban can improve the coagulation and microcirculation indexes in patients with acute myocardial infarction.