痛风泰颗粒加味联合双柏散外敷治疗湿热内蕴型急性痛风性关节炎30例临床观察

Clinical observation on 30 cases of acute gouty arthritis of interior dampness-heat treated with the combination of Tongfengtai Keli and the external application of Shuangbai San

目的观察痛风泰颗粒加味联合双柏散外敷治疗湿热内蕴型急性痛风性关节炎的临床疗效。方法将60例湿热内蕴型急性痛风性关节炎患者按随机数字表法分为对照组和治疗组,各30例。对照组给予双氯芬酸钠双释放肠溶胶囊口服,治疗组给予痛风泰颗粒加味联合双柏散外敷。2组均以7 d为1个疗程,连续治疗2个疗程后比较2组治疗前后血尿酸(BUA)水平、红细胞沉降率(ESR)、C-反应蛋白(CRP)水平、视觉模拟评分法(VAS)评分、中医症状分级量化标准评分及临床疗效。结果 2组治疗后BUA水平、ESR、CRP水平、VAS评分及中医症状分级量化标准评分均显著降低,与同组治疗前比较差异均有统计学意义(P<0.01),且治疗组下降更显著,与对照组治疗后比较差异均有统计学意义(P<0.05);对照组总有效率为73.3%,治疗组为93.3%,2组比较差异有统计学意义(P<0.05)。结论痛风泰颗粒加味联合双柏散外敷治疗湿热内蕴型急性痛风性关节炎临床疗效显著,可明显改善患者的临床症状,提高患者的生活质量,值得临床推广。

Objective To observe the effect of acute gouty arthritis of interior dampness-heat treated with the combination of Tongfengtai Keli and the external application of Shuangbai San. Methods 60 cases of acute gouty arthritis of interior dampness-heat were randomly divided into the treatment group and the control group with 30 cases in each. The control group was given diclofenac sodium double release intestinesol capsule,but the treatment group was given the combination of Tongfengtai Keli and the external application of Shuangbai San. Both were treated for 7 days as one course,then after 2 courses,the clinical effects,BUA,ESR,CRP,VAS,and the scores of Chinese medicine symptoms in two groups were observed and compared. Results After treatment,BUA,ESR,CRP,VAS,and the scores of Chinese medicine symptoms in two groups reduced noticeably,difference in the same group before treatment was significant（ P〈0.01）,and these in the treatment group reduced much more than in the control group,difference had statistical significance（ P〈0.05）; the total effective rate in the treatment group was 93. 3%and 73.3% in the control group with statistical significant difference（ P〈0.05）. Conclusion The combination of Tongfengtai Keli and the external application of Shuangbai San can treat the acute gouty arthritis of interior dampness-heat effectively,which can improve clinical symptoms and patients＇ living standard,be worthy of clinical promotion.