天麻钩藤药膳对高血压鼠的疗效研究

Study on the Curative Effect of Gastrodia elata and Uncaria on Hypertensive Rats

应用天麻钩藤药膳对高血压病鼠进行干预,研究天麻钩藤药膳对肾性高血压病鼠的降压疗效。观察干预前后试验鼠状态、毛发色泽的变化,研究血压、血浆内血管紧张素II (AngII)、内皮素ET-1、NO、动脉组织一氧化氮合酶(eNOS)、尿液中mALB、β_2-MG含量的影响。结果表明,高剂量天麻钩藤药膳提高了试验鼠血清中一氧化氮含量,降低了血管紧张素II (AngII)、内皮素-1 (ET-1)、尿液中mALB与β_2-MG的含量,对于改善自发性肾性高血压具有很强的功效。该结果对于开发以天麻、钩藤为主的纯天然中药药膳,进一步探索调控机制,为临床高血压病的防治提供了理论依据。

The effect of Gastrodia elata and Uncaria on the hypotension of the rats with renal hypertensive disease. Status of rats before and after the intervention, hair color changes, the blood pressure, plasma angiotensin II （Angll） , endothelin, NO, ET-l arterial tissue nitric oxide synthase （eNOS） , mALB, /32-MG content in the urine. Results showed that high dose of Gastrodia elata and Uncaria medicinal food to improve the content of nitric oxide in rats serum, reduces angiotensin II （Angll） , endothelin 1 （ET-l） in the urine, mALB with /32-MG content, to improve the spontaneous renal hypertension has a strong effect. The result was a theoretical basis for the prevention and control of clinical hypertension.