基于关联规则的痤疮中药面膜方用药规律研究

Study on the medication rules of facial mask prescription of traditional Chinese medicine for acne based on association rules

目的分析痤疮中药面膜方的用药规律。方法通过检索中国知网、万方、维普、中国生物医学文献数据库2012年1月~2018年3月含痤疮中药面膜方的中药处方,采用TCMISS中医传承辅助平台软件提取分析处方中各药物的使用频次、四气五味归经、归类以及药物之间的关联规则。结果共搜集到251个中药处方,对其进行分析,其中使用频率较高的中药有大黄、丹参、白芷、黄芩、金银花、黄柏、连翘、蒲公英、黄连、野菊花、苦参等;关键药物组合是"大黄,白芷""大黄,丹参""大黄,黄芩",药物的四气分布主要为寒、凉、温、平,五味分布主要为苦、辛、甘、淡,归经分布主要为肝、胃、心、肺、脾经。结论痤疮外用中药面膜方以"清热活血"为主要治法,核心药物以清热类药物为多,处方用药多以"清热解毒,活血化瘀"为则。

Objective To analyze the medication rules of facial mask prescription of traditional Chinese medicine for ache. Methods The Chinese medicine prescriptions containing facial mask prescription of traditional Chinese medicine for ache were researched from CNKI, Wanfang, VIP, CBM from January 2012 to March 2018, and the frequency of each prescription, four nature of drugs, five flavors, channel tropism, classification and the association rules between drugs were extracted and analyzed by TCMISS Chinese medicine inheritance assistant platform. Results Two hundred and fifty-one Chinese herbal prescriptions were collected. The high frequency herbs were Radix et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Angelieae Dahurieae, Radix Seutellariae, Flos Lonieerae, Cortex Phelladendri, Fruetus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Flos Chryscazthemi Indici, Radix Sophorae Flavescentis, and so on. The key drug combinations were ＂Radix et Rhizoma Rhei, Angelicae Dahuricae＂, ＂Radix et Rhizoma Rhei, Radix Salviae Miltiorrhizae＂, ＂Radix et Rhizoma Rhei, Radix Scutellariae＂. The distribution of four nature of drugs was mainly cold, cool, warm, calm; the distribution of five flavors was mainly bitter, pungent, sweet, tasteless; the distribution of the channel tropism was mainly liver, stomach, heart, lung, spleen channel. Conclusion The facial mask prescription for external use of aene takes ＂clearing heat and activating blood＂ as the main treatment method, and the core drug is mainly for clearing heat; prescription drugs maimly take ＂clearing heat and removing toxicity, promoting blood circula- tion for removing blood stasis＂ as principle.