不同疗程奥美拉唑治疗儿童消化性溃疡的效果对比

Effect comparison of Omeprazole for children with peptic ulcer in different courses of treatment

目的比较不同疗程奥美拉唑治疗儿童消化性溃疡的效果。方法选取2016年1月~2017年6月我院收治的60例患儿作为研究对象,根据14碳呼气试验(14C-UBT)检测结果将其分为幽门螺杆菌(Hp)阳性组(40例)和Hp阴性组(20例)。Hp阴性组患儿随机均分为A组(10例)和B组(10例),Hp阳性组患儿随机均分为C组(20例)和D组(20例)。Hp阴性组中,A组患儿口服奥美拉唑2周,B组患儿给予奥美拉唑4周治疗。Hp阳性组中,C组患儿给予奥美拉唑+阿莫西林克拉维酸钾+克拉霉素2周治疗,D组患儿给予奥美拉唑+阿莫西林克拉维酸钾+克拉霉素2周治疗后,停用抗生素,继续予奥美拉唑治疗2周。Hp阳性组和Hp阴性组患儿均在停药4周于我院进行复查胃镜,Hp阳性组患儿同时行14C-UBT检测,分别比较两组患儿的治疗总有效率及药物不良反应发生率,并比较Hp阳性组患儿的14C-UBT。结果 A、B两组患儿的治疗总有效率及药物不良反应发生率比较,差异无统计学意义(P>0.05)。C、D两组患儿的治疗总有效率及药物不良反应发生率比较,差异无统计学意义(P>0.05)。C、D两组患儿的14C-UBT比较,差异无统计学意义(P>0.05)。结论本研究拟通过对消化性溃疡患儿进行疗程2周及4周的综合疗效对比,为临床提供一种治疗儿童消化性溃疡的短疗程方案,增加患儿依从性、减少药物副作用,减轻患儿家属经济负担,具有较好的社会效益及经济效益。

Objective To compare the effect of Omeprazole for children with peptic ulcer in different courses of treat- ment. Methods Sixty pediatric patients admitted to our hospital from January 2016 to June 2017 were selected as sub- jects. According to C urea breath test （14C-UBT）, the test results were classified into HelicobaCter pylori （Hp） positive group （n=40） and HP negative group （n=20）. In the Hp negative group, they were further divided into group A and group B with 10 cases in each group. In the Hp positive group, they were also further divided into group C and group D with 20 cases in each group. For Hp negative group, oral administration of Omeprazole for 2 weeks in group A was performed, while 4 weeks in group B. For Hp positive group, children in group C were given Omeprazole, Amoxicillin Clavulanate Potassium and Clarithromycin for 2 weeks. After treatment with Omeprazole, Amoxicillin Clavulanate Potassium and Clarithromycin for 2 weeks in group D, antibiotics were discontinued and Omeprazole was continued for 2 weeks. The Hp-positive group and the Hp negative group were all examined in our hospital after stopping the drug for 4 weeks. The Hp positive group was also tested by 14C-UBT. The total effective rate of treatment and the incidence of adverse drug reactions were compared between two groups and 14C-UBT in Hp positive group was compared. Results There were no significant differences in the total effective rate of treatment and the incidence of adverse drug reactions between group A and group B （P〉0.05）. There were no significant differences in the total effective rate of treatment and the incidence of adverse drug reactions between group C and group D （P〉0.05）. There was no significant difference in 142-UBT between group C and group D （P〉0.05）. Conclusion The study intends to provide a short course of treatment for children with peptic ulcer by comparing the comprehensive curative effect of 2 weeks and 4 weeks, increasing com- pliance, reducing side effects of drugs, and reducing economic burden for children＇s parents, which has good social and economic benefits.