胃癌组织中CD147和VEGF的表达及其临床意义

Expression of CD147 and VEGF in Gastric Carcinoma and its Clinical Significance

目的探讨CD147和VEGF在胃癌组织中的表达及其临床意义。方法应用免疫组织化学SP法,检测125例胃癌组织中CD147和VEGF的阳性表达情况。结果胃癌组织中CD147和VEGF阳性率分别为72. 8%和68. 0%;胃癌组织中CD147和VEGF阳性表达与TNM分期及淋巴结转移有关(P<0. 05),而与性别、年龄、分化程度无关; CD147与VEGF在胃癌组织中的表达呈正相关(P<0. 05)。结论检测CD147和VEGF表达对判断胃癌恶性程度、预测其侵袭转移趋势和预后及指导治疗有重要意义。

Objective To explore the expression of CD147 and VEGF in gastric carcinoma and its clinical significance. Methods The expression of CD147 and VEGF was detected in 125 cases of gastric carcinoma by using immunohistochenfical SP method. Results The positive rates of CD147 and VEGF were respectively 72.8% and 68.0%. The expression of CD147 and VEGF in gastric carcinoma was related with TNM stages and lymph node metastasis （P〈0. 05）, but not with sex, age, or tumor cell differentiation （P〉0. 05 ）. The expression of CD147 and VEGF in gastric carcinoma was positively correlated （ P〈0. 05 ）. Conclusions The detection of the expression of CD147 and VEGF is significant for the determination of the extent of malignancy, prediction of the trend of invasion and metastasis, prognosis and treatment guidance of gastric carcinoma.