Epstein-Barr病毒相关T/NK细胞淋巴瘤与B细胞淋巴瘤的临床分析

Clinical analysis of Epstein-Barr virus-associated lymphomas

Epstein-Barr病毒(Epstein-Barr virus,EBV)是可导致人类感染的淋巴滤泡病毒,感染非常普遍。本研究通过对2013年1月—2016年12月于复旦大学附属华东医院就诊并确诊为淋巴瘤且伴有EBV感染的49例患者的临床资料进行回顾性分析,探讨EBV相关淋巴瘤患者的临床特点及生存情况。结果显示,49例EBV相关淋巴瘤患者中,18例为B细胞淋巴瘤,31例为T/NK细胞淋巴瘤。EBV相关B细胞淋巴瘤与T/NK细胞淋巴瘤患者之间白细胞、血小板、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、乳酸脱氢酶、铁蛋白、纤维蛋白原、红细胞沉降率、C反应蛋白的差异有统计学意义(P<0.05)。中位随访5.0个月,49例患者的1个月、6个月、1年、3年生存率分别为84.4%、59.8%、53.2%、40.3%。结果表明,与EBV相关B细胞淋巴瘤患者相比,EBV相关T/NK细胞淋巴瘤患者的肝功能损伤严重,更易合并噬血细胞综合征,生存期更短,但生存期差异无统计学意义。

Epstein-Barr virus （EBV） is a lymphatic follicular virus, and its infection is a very common concern for human health. The present paper aims to investigate the clinical feature and consequences of EBV-associated lymphoma patients. The clinical data of 49 patients who were diagnosed with lymphoma with EBV infection from January 2013 to December 2016 were retrospectively analyzed. Among the 49 EBV-associated lymphoma patients, 18 with B cell lymphoma and 31 with T/NK cell lymphoma. Among the relevant laboratory indicators, inter-group statistical differences existed in white blood cell count, platelet count, alanine aminotransferase level, aspartate aminotransferase level, lactate dehydrogenase level, ferritin level, fibrinogen level, erythrocyte sedimentation rate and C-reactive protein level. The median follow-up period was 5.0 months. The results showed that compared with EBV-associated B cell lymphoma patients, EBV-associated T/NK cell lymphoma patients had more severe liver function damage, more frequency of hemophagocytic syndrome, and shorter survival period. But there was no significant difference in survival period between the two groups （ P 〉 0.05 ）. The 1-month, 6-month, 1-year and 3-year overall survival rates were 84.4% , 59.8% , 53.2% and 40.3% , respectively.