静脉滴注丙种球蛋白辅助治疗新生儿败血症临床研究

Clinical Study of Intravenous Infusion of Gamma Globulin in the Treatment of Neonatal Sepsis

目的探究使用静脉滴注丙种球蛋白的方式进行辅助治疗对于新生儿败血症的临床疗效。方法选取该院在2015年5月—2018年5月期间接受治疗败血症新生儿50例作为研究对象,对照组分别采用头孢曲松及头孢比肟治疗,观察组再联合静脉滴注丙种球蛋白治疗,对比两组患儿的临床疗效。结果观察组患儿的体温改善时间用了(2.36±1.02)d,住院时间为(12.31±1.43)d,PCT水平为(2.15±1.26)ng/L,CRP水平为(13.01±5.38)mg/L,均显著低于对照组患儿(t=2.857、15.446、5.273、6.092,P<0.05);观察组患儿的总有效率为92.00%(23/25),显著高于对照组患儿[72.00%(18/25)](χ~2=7.238,P<0.05)。结论采取抗生素治疗联合静脉输注丙种球蛋白的方式治疗新生儿败血症具有较显著的疗效,值得临床参考。

Objective To investigate the clinical efficacy of adjuvant therapy with intravenous infusion of gamma globulin for neonatal sepsis. Methods A total of 50 neonates with sepsis were treated in the hospital from May 2015 to May 2018. The control group was treated with ceftriaxone and cefotaxime. The observation group was treated with intravenous infusion of gamma globulin, compare the clinical efficacy of the two groups of children. Results In the observation group, the time to improve the body temperature was （2.36±1.02） d, the hospital stay was （12.31±1.43） d, the PCT level was （2.15±1.26） ng/L, and the CRP level was （13.01±5.38） mg/ L, were significantly lower than the control group （t= 2.857, 15.446, 5.273, 6.992, P〈0.05）; the total effective rate of the observation group was 92.00% （23/25）, significantly higher than the control group of children [72.00% （18/25）] （χ2=7.238, P〈0.05）. Conclusion Antibiotic therapy combined with intravenous infusion of gamma globulin has a significant effect in the treatment of neonatal sepsis, which is worthy of clinical reference.