阴道镜联合HPV16.18阳性对宫颈癌及宫颈上皮内瘤变的诊断价值

Diagnostic Value of Colposcopy Combined with HPV16.18 Positive for Cervical Cancer and Cervical Intraepithelial Neoplasia

目的探讨阴道镜联合HPV16.18阳性诊断宫颈癌及宫颈上皮内瘤变的临床价值。方法以2017年1—12月该院妇产科门诊收治的104例疑似宫颈癌患者为研究对象,全部患者均采集阴道分泌物样本进行高危型HPV检测,同时电子阴道镜下宫颈活检,以病理诊断结果为金标准,观察两种方法及联合应用诊断宫颈癌及宫颈上皮内瘤变的检出情况。结果阴道镜联合HPV检测诊断宫颈癌及上皮内瘤病变的灵敏度(98.90%)、符合率(98.07%)、误诊率(1.92%)与病理诊断结果差异无统计学意义(χ~2=0.75,χ~2=0.81,χ~2=0.77,P<0.05)。结论阴道镜联合高危型HPV检测可提高宫颈癌及上皮内瘤病变的诊断鉴别水平,敏感度高,准确性好,能够为宫颈癌及癌前病变早期临床诊治及患者预后改善提供可靠依据,具备推广价值。

Objective To investigate the clinical value of colposcopy combined with HPV16.18 in the diagnosis of cervical cancer and cervical intraepithelial neoplasia. Methods From January to December 2017, 104 patients with suspected cervical cancer admitted to the department of obstetrics and gynecology in the hospital were enrolled. All patients were collected vaginal secretion samples for high-risk HPV testing, and electronic colposcopy under cervical biopsy. Taking the pathological diagnosis as the gold standard, observe the detection of cervical cancer and cervical intraepithelial neoplasia by two methods and combined application. Results The sensitivity （98.90%）, coincidence rate （98.07%）, misdiagnosis rate （1.92%） and pathological diagnosis of colposcopic combined with HPV were not statistically different （χ2=0.75, χ2=0.81, χ2=0.77, P〈0.05）. Conclusion Colposcopy combined with high-risk HPV detection can improve the diagnosis and differentiation of cervical cancer and intraepithelial neoplasia. It has high sensitivity and good accuracy. It can provide a reliable basis for early clinical diagnosis and treatment of cervical cancer and precancerous lesions, with promotion value.