氨氯地平联合厄贝沙坦治疗糖尿病合并高血压的疗效及药学分析

Efficacy and Pharmacological Analysis of Amlodipine Combined with Irbesartan in the Treatment of Diabetes Mellitus Complicated with Hypertension

目的研究厄贝沙坦与氨氯地平联合治疗糖尿病合并高血压的临床效果,并观察其药理作用。方法选择该院2014年2月—2016年4月期间收治的80例糖尿病合并高血压患者作为该次研究对象,按照随机数字表法对其进行分组,分成研究组与对照组,各40例,给予2组患者常规降糖药物,随后对照组应用厄贝沙坦治疗,研究组采取厄贝沙坦与氨氯地平联合治疗,比较2组患者治疗后的临床疗效、舒张压、收缩压以及不良反应发生情况。结果对比2组患者治疗效果,研究组患者治疗总有效率97.50%高于参照组患者75.00%,组间对比统计学意义(χ~2=9.960 5,P<0.05)。治疗后,研究组收缩压(125.1±12.7)mmHg与舒张压(76.4±4.2)mmHg均显著低于对照组,组间差异有统计学意义(t=7.078 1、13.783 7 P<0.05)。研究组不良反应发生率为10.00%,与对照组(15.00%)比较,组间差异无统计学意义(χ~2=0.457 1,P>0.05)。结论厄贝沙坦与氨氯地平联合治疗糖尿病合并高血压的效果显著,能够有效降低患者的舒张压和收缩压,且具有较高的安全性,值得临床应用。

Objective To study the clinical effect of irbesartan combined with amlodipine in the treatment of diabetes mellitus complicated with hypertension, and to observe its pharmacological effects. Methods Eighty patients with diabetes mellitus complicated with hypertension admitted to the hospital from February 2014 to April 2016 were enrolled in this study. They were grouped according to the random number table method. 40 patients in the study group and the control group were given. Two groups of patients were treated with conventional hypoglycemic drugs, followed by irbesartan in the control group. The study group was treated with irbesartan and amlodipine. The clinical efficacy, diastolic blood pressure, systolic blood pressure and adverse reactions of the two groups were compared. Results Comparing the therapeutic effects of the two groups, the total effective rate of the study group was 97.50% higher than that of the reference group（75.00%）. There was statistical significance between the two groups （χ2=9.960 5,P〈0.05）. After treatment, the systolic blood pressure （125.1±12.7）mmHg and diastolic blood pressure （76.4±4.2）mmHg in the study group were significantly lower than those in the control group, and the difference was statistically significant（t=7.078 1、13.783 7,P〈0.05）. The incidence of adverse reactions in the study group was 10.00%. Compared with the control group （15.00%）. There was no significant difference between the two groups（χ2=0.457 1,P〉0.05）. Conclusion Irbesartan combined with amlodipine is effective in the treatment of diabetes with hypertension. It can effectively reduce the diastolic blood pressure and systolic blood pressure of patients, and has high safety and is worthy of clinical application.