羟考酮缓释片与即释吗啡片联合治疗对癌痛患者疼痛程度及疗效的影响

Effect of Oxycodone Sustained-release Tablets Combined with Instant-release Morphine Tablets on the Pains Degree and Curative Effect of Cancer Pain Patients

目的探讨羟考酮缓释片与即释吗啡片联合给药治疗对癌痛患者疼痛程度及疗效的影响。方法选择2016年1月—2018年4月该院肿瘤科癌痛患者112例,按照随机数字表法分成两组,每组56例。对照组患者采用羟考酮缓释片治疗,观察组在对照组患者的治疗基础上联合即释吗啡片治疗。通过疼痛视觉评分(VAS)评价两组患者治疗前、治疗10 d后疼痛程度,及两组患者治疗10 d后临床疗效。结果治疗后,观察组患者临床治疗总有效率明显高于对照组(82.14%vs 50.00%),差异有统计学意义(χ~2=13.47,P<0.05);两组患者VAS疼痛评分均较治疗前降低,且治疗后对比,观察组VAS疼痛评分明显低于对照组,差异有统计学意义(组内:t观察组=19.78,t对照组=4.07;组间:t治疗后=15.12;P<0.05)。结论羟考酮缓释片联合即释吗啡片可以更有效地缓解癌痛患疼痛程度和临床症状,临床疗效显著,在癌痛患者中的应用价值较高。

Objective To study the effect of pains degree and curative effect of oxycodone sustained-release tablets combined with instant-release morphine tablets. Methods 112 cases of patients with cancer pains in our hospital from January 2016 to April 2018 were selected and randomly divided into two groups with 56 cases in each, the control group were treated with oxycodone sustained-release tablets, while the observation group were treated with oxycodone sustained-release tablets combined with instant-release morphine, and the pain degrees before treatment and in 10 d after treatment and clinical curative effect after 10 d of the two groups were evaluated by the VAS. Results After treatment, the total clinical treatment effective rate in the observation group was obviously higher than that in the control group（ 82.14% vs 50.00%）, and the difference was statistically significant（χ~2=13.47, P0.05）; and the VAS pain scores of the two groups decreased compared with those before treatment, and the VAS pain scores in the observation group were obviously lower than those in the control group, and the differences were statistically signficant（in the groups： t in the observation grou P=19.78, t in the control grou P=4.07; between the groups： t after treatment= 15.12,P0.05）. Conclusion The oxycodone sustained-release tablets combined with instant-release morphine can effectively relive the cancer pain degree and clinical symptoms, and the clinical curative effect is obvious, and the application value in the cancer pain patients is high.