猪链球菌毒力因子研究新进展

New Research and Development on Virulence Factors of Streptococcus Suis

猪链球菌(Streptococcus suis, S. suis)是猪链球菌病的主要病原体之一,也是一种重要的人畜共患病病原体。在中国引起了严重的公共卫生问题,可引起脑膜炎、败血症、关节炎、心内膜炎、肺炎等病症。近些年,国内外对猪链球菌研究的重点是发现和鉴定新的毒力因子。该研究着力探讨目前已被广泛研究和新发现的猪链球菌毒力因子,具体包括经典的毒力因子、酶类毒力因子、代谢与调控型毒力因子、Ⅳ型分泌系统、表面锚定蛋白和毒力岛,以期为猪链球菌病疫苗的研制提供新思路。

Streptococcus suis （Streptococcus suis, s. suis） is one of the major pathogens of swine streptococcosis and also an important zoonosis pathogen. Streptococcus suis has caused serious public health problems in China, for it may induce meningitis, septicemia, arthritis, endocarditis, pneumonia, etc. In recent years, the research on streptococcus suis has focused on discovery and identification of new virulence factors. Streptococcal virulence factors which have been widely studied and newly discovered, including the classic virulence factors, enzymes virulence factors, metabolism and regulation virulence factors, Ⅳ secretion systems, surface anchoring proteins and pathogenicity islands, are discussed in this paper in order to provide a new thought for development of streptococcal disease vaccines.