对比替比夫定、恩替卡韦治疗慢性乙型肝炎对肾脏功能的影响

For telbivudine,Effect of Entecavir on Renal Function in Patients with Chronic Hepatitis

目的:分析和比较替比夫定、恩替卡韦治疗慢性乙型肝炎对肾脏功能的影响。方法:回顾分析笔者所在医院收治的67例慢性乙型肝炎患者的临床资料,分为替比夫定组和恩替卡韦组,比较两组肾功能情况。结果:与恩替卡韦组比较,替比夫定组肌酐水平更低(P<0.05),在肾功能正常患者和肾功能轻度受损患者中的肾小球滤过率水平更高(P<0.05),但两组并发症发生率差异无统计学意义(P>0.05)。结论:恩替卡韦在治疗慢性乙型肝炎的过程中对肾功能影响较小,而替比夫定的保肾功能更好。

Objective：To analyze and compare the effects of telbivudine and entecavir on renal function in patients with chronic hepatitis .Methods：Retrospective analysis of the author at the hospital for 67 cases of chronic hepatitis B patients with clinical data were telbivudine group and entecavir group, comparing the two groups of patients with renal function.Results： Patients in the telbivudine group had lower creatinine levels （P〈0.05） compared with entecavir, and had a better glomerular filtration rate in patients with normal renal function and mildly impaired renal function （P〈0.05）, but there was no significant difference in the complication rates between the two groups （P〉0.05）.Ionclusions： Entecavir has little effect on renal function in the treatment of chronic hepatitis B, whereas telbivudine has some benefit in improving renal function in patients.