头孢菌素类抗生素在临床应用中发生的不良反应及应急对策

Adverse reactions and emergency measures of cephalosporin antibiotics in clinical application

目的:研究分析头孢菌素类抗生素在临床应用中发生的不良反应及应急对策。方法:选取我院2015年3月~2017年9月应用头孢菌素类抗生素进行治疗的200例患者,对其发生不良反应的情况与处理情况进行统计分析。结果:200例应用头孢菌素类抗生素治疗的患者中,共出现21例不良反应,不良反应发生率为10.5%,其中有4例血液系统反应、3例胃肠道反应、11例变态反应以及3例肝肾毒性反应。经过及时处理,21例患者均逐渐恢复正常。结论:临床应用头孢菌素类抗生素需要严格遵守相关药物的使用规定,并根据具体病情控制好药物用量,提前做好不良反应的应急预案,尽量降低药物不良反应造成的伤害。

Objective： To study and analyze the adverse reactions and emergency measures of cephalosporin antibiotics in clinical application. Methods： A total of 200 patients treated with cephalosporin antibiotics from March 2015 to September 2017 in our hospital were selected for statistical analysis of their adverse reactions. Results： A total of 21 adverse reactions were observed in 200 patients treated with cephalosporin antibiotics. The incidence of adverse reactions was 10.5%. There were 4 hematological reactions, 3 gastrointestinal reactions, 11 allergic reactions and 3 cases of liver and kidney toxicity. After timely treatment, 21 patients gradually returned to normal. Conclusion： The clinical application of cephalosporins antibiotics need to strictly abide by the relevant provisions of the use of drugs, and according to the specific condition of the patient to control the amount of drugs, early response to emergency response plans to minimize adverse drug reactions to patients caused by re-injury.