耳垂皱褶与冠心病的关系研究

Relationship between Earlobe Creases and Coronary Heart Disease

目的探讨耳垂皱褶与冠心病的关系。方法连续选取2014年5—8月在江苏省人民医院行冠状动脉造影检查者443例,其中无耳垂皱褶者146例,单侧耳垂皱褶者71例,双侧耳垂皱褶者226例;有冠心病者353例,无冠心病者90例。比较无、单侧、双侧耳垂皱褶者一般资料、实验室检查指标、冠心病发生情况及Gensini积分,并比较有无冠心病者一般资料、实验室检查指标及耳垂皱褶情况;耳垂皱褶与冠心病的关系分析采用多因素Logistic回归分析。结果 (1)无、单侧、双侧耳垂皱褶者吸烟率、舒张压、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白及低密度脂蛋白比较,差异无统计学意义(P>0.05);单侧和双侧耳垂皱褶者年龄大于无耳垂皱褶者,男性比例、收缩压、冠心病发生率及Gensini积分高于无耳垂皱褶者(P<0.05);双侧耳垂皱褶者冠心病发生率和Gensini积分高于单侧耳垂皱褶者(P<0.05)。(2)有无冠心病者年龄、男性比例、吸烟率、耳垂皱褶情况比较,差异有统计学意义(P<0.05);有无冠心病者收缩压、舒张压、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白比较,差异无统计学意义(P>0.05)。(3)多因素Logistic回归分析结果显示,单侧耳垂皱褶[OR=3.752,95%CI(1.751,8.037)]和双侧耳垂褶皱[OR=6.880,95%CI(3.863,12.255)]是冠心病的独立影响因素(P<0.05);根据性别进行亚组分析结果显示,单侧和双侧耳垂皱褶分别是男性[单侧耳垂皱褶:OR=3.763,95%CI(1.445,9.801);双侧耳垂皱褶:OR=5.758,95%CI(2.753,12.042)]、女性[单侧耳垂皱褶:OR=3.636,95%CI(1.011,13.093);双侧耳垂皱褶:OR=8.909,95%CI(3.537,22.439)]冠心病的独立影响因素(P<0.05)。结论单侧、双侧耳垂皱褶是冠心病的独立影响因素,双侧耳垂皱褶者冠心病发生风险高于单侧耳垂皱褶者,且耳垂皱褶与冠状动脉狭窄程度有关。

Objective To investigate the relationship between earlobe creases and coronary heart disease. MethodsA total of 443 subjects undergoing coronary angiography were continuously selected in Jiangsu Provincial People＇s Hospital from May to August in 2014,there into 146 cases without earlobe creases were served as A1 group,71 cases with unilateral earlobe crease were selected as A2 group,226 cases with bilateral earlobe creases were served as A3 group;353 cases with coronary heart disease were served as B1 group,the other 90 cases without coronary heart disease were served as B2 group. General information,laboratory examination results,incidence of coronary heart disease and Gensini score were compared in A1 group,A2 group and A3 group,general information,laboratory examination results and earlobe creases status were compared between B1 group and B2 group relationship between earlobe creases and coronary heart disease was analyzed by multivariateLogistic regression analysis. Results（1）No statistically significant differences of smoking rate,DBP,FPG,TC,TG,HDL or LDL was found in A1 group,A2 group and A3 group（P〉0.05）;age in A2 group and A3 group was statistically significantly older than that in A1 group,respectively,meanwhile male proportion,SBP,incidence of coronary heart disease and Gensini score in A2 group and A3 group were statistically significantly higher than those in A1 group（P〈0.05）;incidence of coronary heart disease and Gensini score in A3 group were statistically significantly higher than those in A2 group（P〈0.05）.（2）There were statistically significant differences of age,male proportion,smoking rate and earlobe creases status between B1 group and B2 group（P〈0.05）,while no statistically significant differences of SBP,DBP,FPG,TC,TG,HDL or LDL was found between B1 group and B2 group（P〉0.05）.（3）Multivariate Logistic regression analysis results showed that,unilateral earlobe crease〔OR=3.752,95%CI（1.751,8.037）〕and bilateral earlobe creases〔OR=6.880,95%CI（3.863,12.255）〕were independent influencing factors of coronary heart disease（P〈0.05）;subgroup analysis results depended on gender showed that,unilateral earlobe crease and bilateral earlobe creases were still independent influencing factors of coronary heart disease in males〔unilateral earlobe crease：OR=3.763,95%CI（1.445,9.801）;bilateral earlobe creases：OR=5.758,95%CI（2.753,12.042）〕and in females〔unilateral earlobe crease：OR=3.636,95%CI（1.011,13.093）;bilateral earlobe creases：OR=8.909,95%CI（3.537,22.439）〕,respectively（P〈0.05）. ConclusionUnilateral earlobe crease and bilateral earlobe creases are independent influencing factors of coronary heart disease,bilateral earlobe creases may significantly increase the risk of coronary heart disease compared with unilateral earlobe crease,and earlobe creases was significantly correlated with degree of coronary artery stenosis.