尼莫地平联合神经节苷脂治疗高血压脑出血的临床疗效及其对炎性因子、氧化应激的影响

Clinical Effect of Nimodipine Combined with Ganglioside on Hypertensive Cerebral Hemorrhage and the Impact on Inflammatory Cytokines and Oxidative Stress

目的观察尼莫地平联合神经节苷脂治疗高血压脑出血的临床疗效,并探讨其对炎性因子、氧化应激的影响。方法选取2016年8月—2017年8月成都市天府新区人民医院收治的高血压脑出血患者100例,采用简单随机抽样法分为对照组和观察组,每组50例。对照组患者采用常规治疗,观察组患者在对照组基础上加用尼莫地平联合神经节苷脂治疗;两组患者均连续治疗2周。比较两组患者临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、血清炎性因子水平、氧化应激指标,并观察两组患者治疗期间不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前两组患者NIHSS评分比较,差异无统计学意义(P>0.05);治疗后观察组患者NIHSS评分低于对照组(P<0.05)。治疗前两组患者血清白介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血清IL-6、CRP、TNF-α水平低于对照组(P<0.05)。治疗前两组患者髓过氧化物酶(MPO)、脂质过氧化物(LPO)、丙二醛(MDA)、超氧化物歧化酶(SOD)比较,差异无统计学意义(P>0.05);治疗后观察组患者MPO、LPO、MDA低于对照组,SOD高于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论尼莫地平联合神经节苷脂治疗高血压脑出血的临床疗效确切,可有效促进患者神经功能恢复,降低血清炎性因子水平,减轻氧化应激,且安全性较高。

ObjectiveTo observe the clinical effect of nimodipine combined with ganglioside on hypertensive cerebral hemorrhage,to investigate the impact on inflammatory cytokines and oxidative stress. MethodsFrom August 2016 to August 2017,a total of 100 patients with hypertensive cerebral hemorrhage were selected in the People＇s Hospital of Tianfu New District,Chengdu,and they were divided into control group and observation group according to simple random sampling method,each of 50 cases. Patients in control group received conventional treatment,while patients in observation group receive nimodipine combined with ganglioside based on that of control group;both groups continuously treated for 2 weeks. Clinical effect,NIHSS score,serum inflammatory cytokines levels and index of oxidative stress before and after treatment were compared between the two groups,and incidence of adverse reactions was observed during treatment. ResultsClinical effect in observation group was statistically significantly better than that in control group（P〈0.05）. No statistically significant differences of NIHSS score was found between the two groups before treatment（P〉0.05）,while NIHSS score in observation group was statistically significantly lower than that in control group（P〈0.05）. No statistically significant differences of serum level of IL-6,CRP or TNF-α was found between the two groups before treatment（P〉0.05）,while serum levels of IL-6,CRP and TNF-α in observation group were statistically significantly lower than those in control group after treatment（P〈0.05）. No statistically significant differences of MPO,LPO,MDA or SOD was found between the two groups before treatment（P〉0.05）;after treatment,MPO,LPO and MDA in observation group were statistically significantly lower than those in control group,while SOD in observation group was statistically significantly higher than that in control group（P〈0.05）. No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment （P〉0.05） . ConclusionNimodipine combined with ganglioside has certain clinical effect in treating hypertensive cerebral hemorrhage,can effectively promote the recovery of neurological function,reduce the serum inflammatory cytokines levels and reduce the oxidative stress with relatively high safety.