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C1GALT1基因变异与IgA肾病遗传易感性的相关性研究

Correlation between genetic variations of C1GALT1 gene and genetic susceptibility to IgA nephropathy
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摘要 目的通过病例对照关联研究,研究分析C1GALT1和C1GALT1C1基因的单核苷酸多态性(single nucleotide polymorphisms,SNPs)与新疆地区维吾尔族人群IgA肾病(IgA nephropathy,IgAN)易感性之间的关联。方法共选取1 014名受试者,其中包括595名IgAN患者和419名地理和民族匹配的健康对照者。选择C1GALT1中的-734C/T,-465A/G,-330G/T,-292C/-和1365G/A 5个SNPs作为标记SNP。结果 IgAN患者-292C/-的D等位基因和DD基因型显著低于对照组(P<0. 01)。IgAN患者的单倍型YATIG(Y=C或T)频率显著低于对照组(0. 0726 vs 0. 1202,P=2. 684×10-4,OR=0. 68)。IgAN患者的单倍型YAGDA(0. 1187 vs0. 0684,P=3. 671×10-3,OR=1. 72)和YATDG(0. 0827 vs 0. 0275,P=1. 197×10-5,OR=2. 87)显著高于对照组。结论 C1GALT1基因的变异与新疆地区维吾尔族IgAN遗传易感性相关。 Objective To investigate the relationship between the single nueleotide polymorphisms (SNPs) of C1GALT1 and C1GALT1C1 genes and the susceptibility of IgA nephropathy (IgAN) in Xinjiang Uygur population through a ease-control association study. Methods A total of 1 014 subjects were selected, including 595 IgAN patients and 419 geographically and ethnically matched healthy controls. Five SNPs, -734C/T, -465A/G, -330G/T, -292C/-, and 1365G/A in C1GALT1, were selected as marker SNPs. Results The D allele and DD genotype of -292C/- in IgAN patients were significantly lower than those in the control group (P〈0.01). The frequeney of haplotype YATIG (Y = C or T) was significantly lower than that of the control group (0. 0726 vs 0. 1202, P=2. 684×10^-4, OR=0. 68). Patients with haplotype YAGDA (0. 1187 vs 0. 0684, P=3. 671×10^-3, OR = 1.72) and YATDG (0. 0827 vs 0. 0275, P = 1. 197 ×10^-5, OR higher than those in the control group. Conclusion This study suggests 2. 87 ) were significantly that the C1GALT1 gene polymorphism is associated with genetic susceptibility to IgAN in Xinjiang Uygur people.
作者 黄海 列才华 梁兰青 屈姗 郭志勇 HUANG Hai;LIE Caihua;LIANG Lanqing;QU Shah;GUO Zhiyong(Department of Nephrology,Changhai Hospital,Naval Military Medical University,Shanghai 200433,China;Department of Nephrology,Xinjiang Military Area General Hospital,Urumqi Xinjiang 830002,China)
出处 《转化医学杂志》 2018年第5期268-271,共4页 Translational Medicine Journal
基金 新疆维吾尔自治区自然科学基金资助项目(2015211C236)
关键词 CIGALT1基因 单核苷酸多态性 IGA肾病 C1GALT1 gene Single nueleotide polymorphisms (SNPs) IgA nephropathy (IgAN)
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  • 1陈香美,谢院生.重视延缓IgA肾病进展的基础和临床研究[J].中华肾脏病杂志,2004,20(4):235-237. 被引量:155
  • 2陈香美,谢院生.IgA肾病的发病与治疗[J].中国中西医结合肾病杂志,2006,7(12):683-686. 被引量:30
  • 3Donadio JV, Grande JP. lgA nephropathy. N Engl J Med, 2002, 347(10) :738 - 748.
  • 4Radford MG Jr, Donadio JV Jr, Bergstrahl EJ, et al. Predicting renal outcome in IgA nephropathy. J Am Soc Nephrol, 1997,8 (2) : 199 - 207.
  • 5D'Altri C, Manno C, Rossini M, et al. Studio clinicopatologico retrospettivo in 543 pazienty affetti da nefropatia IgA. Giorn It Nefrol, 2001,18 : 425 - 432.
  • 6Floege J, Feehally J. IgA nephropathy: Recent developments. J Am Soc Nephrol, 2000,11 (12) : 2395 - 2403.
  • 7U. S. Renal Data System, USRDS 1999 Annual Data Report, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda.
  • 8Maisonneuve P, Agodoa L, Gellert R, et al. Distribution of primary renal diseases leading to end - stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study. Am J Kidney Dis, 2000,35 ( 1 ) : 157- 165.
  • 9Glassock RJ, Kurokawa K, Yoshida M, et al. IgA nephropathy in Japan. Am J Nephml, 1985,5(2) : 127 - 137.
  • 10Schena FP. Coppo R IgA nephropathies. In. Davison AM, Cameron JS, Grufeld JP, et al. van T Persele C (eds) Oxford textbook of clinical nephrology, Oxford University Press, Oxford,2005,3:469 - 501.

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