阿卡波糖与二甲双胍治疗糖尿病前期的效果

Effect of acarbose and metformin in the treatment of pre-diabetes

目的探讨阿卡波糖与二甲双胍治疗糖尿病前期的效果。方法将我院收治的130例糖尿病前期患者随机分为两组,各65例。对照组采用二甲双胍治疗,观察组采用阿卡波糖治疗。观察两组治疗前、后相关指标及血糖水平,比较两组患者血糖控制率、糖尿病发生率及不良反应发生率。结果治疗后,观察组患者的BMI、TC、TG水平、SBP、DBP均低于治疗前,TG水平、SBP、DBP均低于对照组(P<0.05)。治疗后,两组患者的空腹血糖及餐后2 h血糖均降低,且观察组均低于对照组(P<0.05)。观察组患者血糖控制率高于对照组,糖尿病发生率低于对照组(P<0.05)。观察组的不良反应总发生率低于对照组(P<0.05)。结论阿卡波糖与二甲双胍治疗糖尿病前期患者临床效果佳,但阿卡波糖预防糖尿病作用更好,且无明显毒副反应,值得临床应用。

Objective To investigate the effect of acarbose and metformin in the treatment of pre-diabetes. MethodsA total of 130 patients with pre-diabetes admitted in our hospital were randomly divided into two groups, with 65 casesin each group. The control group was treated with metformin, and the observation group was treated with acarbose. Therelated indicators and levels of blood glucose before and after treatment in the two groups were observed, the bloodglucose control rates, incidences of diabetes and adverse reactions of the two groups were compared. Results Aftertreatment, the BMI, levels of TG, SBP and DBP in the observation group significantly decreased, and levels of TG, SBP,DBP in the observation group were lower than those in the control group （P〈0.05）. After treatment, the levels of fastingblood glucose and postprandial 2 h blood glucose decreased in both groups, and those in the observation group werelower than the control group （P〈0.05）. The blood glucose control rate in the observation group was higher than that inthe control group, and the incidence of diabetes was lower than that in the control group （P〈0.05）. The total incidenceof adverse reactions in the observation group was lower than that in the control group （P〈0.05）. Conclusion Acarboseand metformin have good clinical effects on pre -diabetes, but acarbose is more effective, and there is no obviousadverse reaction. It is worthy of clinical application.