氢氧化钙与樟脑酚治疗慢性牙髓炎的临床效果

Clinical effect of calcium hydroxide and camphor phenol in the treatment of chronic pulpitis

目的研究氢氧化钙与樟脑酚治疗慢性牙髓炎的临床效果。方法选取我院2015年9月至2016年9月收治的90例慢性牙髓炎患者为研究对象,以随机数表法分为观察组与对照组,各45例。观察组采用氢氧化钙治疗,对照组采用樟脑酚治疗。比较两组治疗前、后患牙疼痛评分、患牙活动度评分、血清和龈沟液中的肿瘤坏死因子-α(TNF-α)、白细胞介数-8(IL-8)水平及临床疗效,记录两组用药后的不良反应发生情况。结果治疗后,两组患者患牙疼痛及活动度评分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者血清及龈沟液TNF-α、IL-8水平均降低,且观察组低于对照组,差异具有统计学意义(P<0.05);观察组治疗总有效率为86.67%,高于对照组的64.44%,差异具有统计学意义(P<0.05);观察组用药后不良反应总发生率为4.44%,低于对照组的20.00%,差异具有统计学意义(P<0.05)。结论氢氧化钙治疗慢性牙髓炎临床疗效显著,可降低患者疼痛和患牙活动度,抑制炎症反应,且不良反应发生率低,值得临床推广。

Objective To study the clinical effect of calcium hydroxide and camphor phenol in the treatment of chronicpulpitis. Methods A total of 90 patients with chronic pulpitis treated in our hospital from September 2015 to September2016 were selected as the study objects and divided into observation group and control group according to the randomnumber table method, with 45 cases in each group. The observation group was treated with calcium hydroxide, and thecontrol group was treated with camphor phenol. The tooth pain scores, tooth activity scores, levels of tumor necrosisfactor-琢 （TNF-琢） and leukocyte mediator-8 （IL-8） in serum and gingival crevicular fluid before and after treatment andclinical efficacy were compared between the two groups, and the adverse reactions were recorded. Results Aftertreatment, the scores of tooth pain and activity of the two groups reduced, and those of the observation group were lowerthan the control group, the differences were statistically significant （P〈0.05）; After treatment, the levels of TNF-琢 andIL-8 in serum and gingival crevicular fluid of the two groups reduced, and those of the observation group were lowerthan the control group, the differences were statistically significant （P〈0.05）. The total effective rate of treatment in theobservation group was 86.67%, which was higher than 64.44% of the control group, and the difference was statisticallysignificant （P〈0.05）. The total incidence of adverse reactions in the observation group was 4.44%, which was lower than20.00% of the control group, and the difference was statistically significant （P〈0.05）. Conclusion Calcium hydroxide inthe treatment of chronic pulpitis has a significant clinical effect, which can reduce tooth pain and activity, inhibit inflammation reactions, and the incidence of adverse reactions is low. It is worthy of clinical promotion.