肝动脉介入化疗栓塞术与还原型谷胱甘肽治疗对晚期肝癌患者肝功能恢复的影响

Effect of hepatic artery interventional embolization and glutathione therapy on liver function recovery in elderly patients with advanced liver cancer

目的探讨肝动脉介入化疗栓塞(TACE)术联合还原型谷胱甘肽方案治疗晚期肝癌对肝功能恢复产生的影响。方法选取2016年2月至2017年3月在本院治疗的84例晚期肝癌患者分为对照组(常规药物化疗,n=42)、观察组(TACE术联合还原型谷胱甘肽治疗),对比患者肝功能指标变化情况。结果观察组治疗后肝功能各项指标均无明显变化(P> 0. 05),且明显低于对照组(P <0. 05);观察组治疗后生命质量总评分高于对照组,不良反应发生率低于对照组(P <0. 05)。结论给予晚期肝癌患者TACE术联合还原型谷胱甘肽治疗,可使患者肝功能得到更大程度改善,总疗效更理想。

Objective To investigate the effect of transcatheter arterial chemoembolization（TACE）combined with reduced glutathione on the recovery of liver function in elderly patients with advanced liver cancer. Methods 84 elderly patients with advanced liver cancer who were treated in our hospital from February 2016 to March 2017 were divided into control group（conventional drug chemotherapy）,observation group（TACE ＋ glutathione treatment）,and the changes of liver function indexes were compared. Results No significant changes in liver function were observed in the observation group after treatment（ P 〉 0.05）,which was significantly lower than that in the control group（ P 〈 0.05）.The total score of quality of life in the observation group was higher than that in the control group,and the incidence of adverse reactions was lower than that in the control group（ P 〈 0.05）. Conclusion The treatment of TACE and glutathione for the elderly patients with advanced liver cancer can improve the liver function of the patients to a greater degree,and the total curative effect is more ideal.