精神分裂症患者认知功能障碍应用文拉法辛治疗的效果研究

Effect of venlafaxine on cognitive dysfunction in schizophrenic patients

分析文拉法辛治疗精神分裂症患者认知功能障碍的临床疗效,选择2015年7月—2017年5月收治的50例精神分裂具有认知功能障碍患者,随机分为观察组和对照组,两组均采取常规治疗,对照组使用安慰剂治疗,观察组使用文拉法辛治疗,治疗1年后使用韦氏成人记忆量表评价患者认知功能情况,采取生活质量综合评定问卷-74(GQO-74)评价生活质量情况。经过不同临床治疗后,两组患者认知功能和生活质量均获得明显改善,而观察组显著优于对照组(P<0.05)。对于精神分裂症认知障碍患者,使用文拉法辛治疗可明显提高患者认知功能,改善患者生活质量,值得临床推广使用。

To analyze the clinical efficacy of venlafaxine in the treatment of cognitive impairment in schizophrenic patients,50 schizophrenic patients with cognitive impairment were randomly divided into observation group and control group from July 2015 to May 2017. After one year of treatment,the cognitive function of the patients was evaluated with Wechsler Adult Memory Scale,and the quality of life was assessed with GQO-74. After different clinical treatment,cognitive function and quality of life of two groups were significantly improved, and the observation group was significantly better than the control group（ P〈0. 05）. For schizophrenic patients with cognitive impairment,venlafaxine therapy can significantly improve cognitive function,and improve the quality of life of patients,which is worthy of clinical promotion.