抗菌肽联合替硝唑治疗慢性牙周炎临床研究

Clinical Study on Antibacterial Peptide Combined with Tinidazole in the Treatment of Chronic Periodontitis

目的探讨抗菌肽联合替硝唑片治疗慢性牙周炎的疗效及对龈沟液炎性因子水平的影响。方法将医院口腔科2015年1月至2017年3月收治的慢性牙周炎患者87例,按随机数字表法分为对照组(44例)和观察组(43例)。两组患者均给予牙周基础治疗,对照组患者加用替硝唑口服治疗,治疗组患者在对照组患者治疗基础上联合抗菌肽治疗,2个疗程后对比疗效。结果观察组总有效率为97. 67%,明显高于对照组的81. 82%(χ~2=4. 310,P <0. 05);治疗后,两组患者可溶性细胞间黏附分子-1(s ICAM-1)、白细胞介素1β(IL-1β)、单核细胞趋化蛋白-1(MCP-1)、牙周探诊深度(PPD)、菌斑指数(PLI)、牙周附着水平(PAL)、牙齿松动度(TMD)水平均下降,且观察组较对照组降低更明显(P <0. 05);两组不良反应发生率相当(6. 98%比18. 18%,P> 0. 05)。结论抗菌肽联合替硝唑治疗慢性牙周炎,能有效缓解牙周组织炎症,改善龈沟液环境,疗效确切,且不良反应较少,值得临床推广。

Objective To investigate the clinical effect of antibacterial peptide combined with tinidazole in the treatment of chronic periodontitis and its effect on the inflammatory factor level in gingival crevicular fluid. Methods Totally 87 patients with chronic periodontitis admitted to the Department of Stomatology in our hospital from January 2015 to March 2017 were divided into the control group（ 44 cases） and the observation group（ 43 cases） according to the random number table method. The two groups were given periodontal basic treatment,on this basis,the control group was given tinidazole orally,while the observation group was given antibacterial peptides on the basis of the control group. After 2 courses of treatment,the curative effect was compared. Results The total effective rate of the observation group was 97. 67%,which was significantly higher than 81. 82% of the control group（ χ^2 = 4. 310,P〈0. 05）. After treatment,the levels of soluble intercellular adhesion molecule-1（ sICAM-1）,interleukin-1β（ IL-1β）,monocyte chemoattractant protein-1（ MCP-1）,periodontal probing depth（ PPD）,plaque index（ PLI）,periodontal attachment level（ PAL） and tooth mobility（ TMD） in the two groups were decreased,and the decrease in the observation group was more significant than that in the control group（ P 〈0. 05）. The incidence rates of adverse reactions in the two groups were similar（ 6. 98% vs. 18. 18%,P 〉0. 05）. Conclusion Antibacterial peptide combined with tinidazole in the treatment of chronic periodontitis can effectively alleviate periodontal tissue inflammation and improve the environment of gingival crevicular fluid. It has a definite effect and few adverse reactions,which is worthy of clinical promotion.