痰热清联合炎琥宁治疗儿童支原体肺炎50例临床观察

Clinical Observation on Tanreqing Combined with Yanhuning in the Treatment of 50 Children Patients with Mycoplasma Pneumonia

目的观察痰热清注射液联合炎琥宁治疗儿童支原体肺炎(MP)的疗效。方法选择医院2016年1月至2018年1月收治的MP患儿95例,按治疗方式的不同分为观察组(50例)和对照组(45例)。两组患儿均进行常规对症治疗和抗生素治疗,包括退热、止咳、平喘、雾化治疗,口服阿奇霉素片,并给予炎琥宁治疗,观察组患儿在此基础上加用痰热清注射液治疗,均治疗2周。结果观察组总有效率为90. 00%,显著高于对照组的73. 33%(P <0. 05);观察组患儿体温降至正常、喘息消失、咳嗽消失、肺部湿罗音消失时间均明显短于对照组患儿(P <0. 05);治疗后,两组患儿血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)水平均降低,且观察组各指标水平均低于对照组(P <0. 05);两组不良反应发生率相当(14. 00%比6. 67%,P> 0. 05)。结论痰热清注射液联合炎琥宁治疗儿童MP疗效显著,能快速改善患儿临床症状,降低炎性因子水平,且不良反应少,可进一步推广。

Objective To observe the curative effect of Tanreqing combined with Yanhuning in the treatment of children patients with mycoplasma pneumonia（ MP）. Methods Totally 95 children patients with MP admitted to our hospital from January 2016 to January2018 were selected and divided into the observation group（ n = 50） and the control group（ n = 45） according to different treatment methods. Both groups were given routine symptomatic treatment and antibiotic therapy,included antipyretic,relieving cough and asthma,nebulization treatment,oral administration of azithromycin,and treated with Yanhuning. The observation group was treated with Tanreqing Injection on the basis of treatment. All patients were treated for 2 weeks. Results The total effective rate of the observation group was90. 00%,which was significantly higher than 73. 33% of the control group（ P〈0. 05）. The time of body temperature dropped to normal,the fading time of asthmatic,coughing and crackles and rale in the observation group was significantly shorter than that in the control group（ P〈0. 05）. After treatment,the levels of serum procalitonin（ PCT）,high-sensitivity C-reactive protein（ hs-CRP） and interleukin-6（ IL-6） in the two groups were decreased,and those in the observation group were lower than those in the control group（ P〈0. 05）.The incidence rates of adverse reactions in the two groups were similar（ 14. 00% vs. 6. 67%,P〉0. 05）. Conclusion Tanreqing Injection combined with Yanhuning is effective in the treatment of children patients with MP,it can rapidly improve the clinical symptoms of children patients,reduce the level of inflammatory factors,and has fewer adverse reactions,which can be further promoted.