RbAP48与恶性肿瘤的研究进展

Research progress of RbAP48 and malignant tumors

视网膜母细胞瘤结合蛋白48(Retinoblastoma associated protein 48,Rb AP48)是一种新型肿瘤特异性蛋白,属于WD-40蛋白家族成员,作为一种Rb结合蛋白,是从不同染色质组装、装配及核小体修饰复合物(包括组蛋白乙酰化酶HDACs)分离出来的第一个被鉴定的高峰度蛋白,在Rb/E2F信号传导通路中起转录抑制作用。研究证实,Rb AP48通过HDAC1靶向作用于视网膜母细胞瘤蛋白Rb,从而结合形成Rb·HDAC1·Rb AP48三聚复合体,该复合物在G1期定位于E2F上,抑制该调节因子转录。Rb AP48在肺癌、宫颈癌、甲状腺癌、急性髓系白血病、乳腺癌、胃癌和原发性肝癌等恶性肿瘤中均表达异常,并且与肿瘤的发生发展关系密切,因此,进一步了解Rb AP48的作用及在不同种类肿瘤中的表达情况对了解肿瘤的发生发展有重要意义。

Retinoblastoma associated protein 48（RbAP48）is a new kind of tumor-specific protein belong to the WD-40 family of proteins.As a Rb-binding protein,it is the first identified peak protein isolated by different chromatin assembly,assembly and nucleosomal modification complexes（including histone acetylase HDACs）,separating the first peak of identified proteins,in Rb/E2F transcription inhibition role in the signal transduction pathway.which is localized on E2F at the G1 phase and inhibits the transcription of this regulatory factor.At present,RbAP48 is abnormally expressed in malignant tumors such as lung cancer,cervical cancer,thyroid cancer,acute myeloid leukemia,breast cancer,gastric cancer and primary liver cancer,and it is closely related to the occurrence and development of tumors.Therefore,inorder to learn more about their interactions,RbAP48 is expressed in different kinds of tumors in the have important implications for understanding the occurrence of tumor development.