β-连环蛋白在软组织肿瘤中的研究进展

Advance in the role of β-catenin in soft tissue tumors

β-连环蛋白(β-catenin)作为一种胞浆蛋白及转录蛋白在肿瘤的发生发展中起双重作用。近年来,β-catenin及其相关Wnt/β-catenin信号通路在肿瘤中的异常调节受到越来越多的关注。软组织肉瘤好发于四肢及躯干,在中青年人群中发病率较高,其分类复杂,进展期恶性程度较高,亟待靶向药物缓解病程进展。本文就β-catenin在软组织肉瘤中的表达模式及其在增殖、转移、凋亡、分化、自我更新方面的相关作用机制进行全面概括,以期改善患者的临床预后,为软组织肿瘤的靶向治疗带来新希望。

As a cytoplasmic protein and transcriptional protein,β-catenin plays a dual role in the occurrence and development of tumors.In recent years,the abnormal regulation of β-catenin and its related Wnt/β-catenin signaling pathway in tumors have attracted more and more scholars＆apos; attention.Soft tissue sarcoma occurs in the limbs and trunks,especially in young and middle-aged people.The classification of soft tissue sarcoma is complicated,and the degree of malignancy is high in advanced phase.It is urgent to target drugs to alleviate the progress of this disease.In this paper,the expression pattern of β-catenin in soft tissue tumors and its related mechanisms involved in the proliferation,metastasis,apoptosis,differentiation and self-renewal of soft tissue sarcomas are comprehensively summarized in order to improve the clinical prognosis of patients and bring new hope for targeted therapy.