肥胖与结直肠癌发病机制的研究进展

Research progress in the pathogenesis of obesity and colorectal cancer

肥胖是由于机体能量长期供过于求,过多的脂肪在体内堆积所致。近年来,随着人们物质水平的提高以及生活习惯的改变,肥胖人群所占的比例越来越多,并成为结直肠癌发生发展的高危因素。肥胖所致结直肠癌发病机制有多种,包括瘦素、脂联素和炎症因子等脂肪因子的作用,以及胰岛素抵抗、miRNA、微量元素、维生素、氧化应激反应和肠道微生态紊乱等方面的原因。本文对其作用机制的研究进展加以综述,以期对结直肠癌的预防和治疗起到积极的指导作用。

Obesity is caused by the long-term supply of energy in the body and the accumulation of excess fat in the body.In recent years,with the improvement of life quality and changes in living habits,the proportion of obese people is increasing,and it is a high risk factor for the development of colorectal cancer.There are many pathogeneses of colorectal cancer caused by obesity,including the action of adipokines such as leptin,adiponectin and inflammatory factor as well as insulin resistance,regulations of miRNA genes,trace elements,vitamin,microelement,oxidative stress response and intestinal microecological disorders.This article reviews the research progress in its mechanism of action,in order to provide guidance for the prevention and treatment of colorectal cancer.