PD-L1的表达与妇科恶性肿瘤预后关系的研究进展

Advances in the relationship between the PD-L1 expression and the prognosis of gynecologic malignancies

程序性死亡蛋白1(Programmed death protein 1,PD-1)是T细胞上主要存在的一种抑制性受体。程序性死亡配体-1(Programmed death ligand-1,PD-L1,又称B7-H1)在心、肝、肾、肺等多个器官上皮细胞和内皮细胞中广泛表达。肿瘤发生时机体内的肿瘤微环境会使浸润性T细胞高表达PD-1,同时肿瘤细胞中PD-L1的表达上调,与PD-1受体相结合,导致肿瘤微环境中PD-1通路持续开放,进而导致T细胞凋亡,肿瘤细胞则逃脱机体的免疫监视,发生肿瘤免疫逃逸。本文就PD-L1表达与妇科恶性肿瘤预后关系的研究进展进行综述。

Programmed death protein 1（PD-1）is a major inhibitory receptor in T cells.Programmed death ligand-1（PD-L1,also known as B7-H1）is widely expressed in epithelial cells and endothelial cells of many organs such as heart,liver,kidney and lung.Tumor microenvironment in tumorigenesis causes invasive T cells to express PD-1,and PD-L1 is up-regulated in tumor cells,which binds to the PD-1 receptor,resulting in sustained PD-1 pathway in tumor microenvironment,inducing T cell apoptosis and escaping the immune surveillance to cause tumor immune escape.This article reviews the research progress of the relationship between the expression of PD-L and the prognosis of gynecologic malignancies.