老年痴呆患者血浆同型半胱氨酸水平的分析

Detection of Plasma Homocysteine Level in Elderly Patients with Dementia

目的:探讨血浆同型半胱氨酸(Hcy)水平与老年痴呆病情程度的相关性。方法:将我院2015年10月至2017年10月收治的老年痴呆患者146例,采用中文版简易精神状态量表(CMMSE)将患者分为轻度、中度、重度;依据Hachinski缺血指数量表将患者分为血管性痴呆(VD)、混合性痴呆(MD)及阿尔茨海默病(AD)。另选取同期健康体检者43例为对照组,采用循环酶方法检测血浆Hcy水平,分析Hcy水平与老年痴呆病情程度相关性。结果:AD、MD、VD患者血浆Hcy水平分别为(25.24±6.77)μmol/L、(24.12±4.32)μmol/L、(26.57±5.27)μmol/L,均明显高于对照组[(10.26±4.33)μmol/L],差异有统计学意义(P<0.05)。轻度、中度、重度老年痴呆患者血浆Hcy水平分别为(20.84±4.97)μmol/L、(25.98±5.34)μmol/L、(32.84±4.06)μmol/L,均明显高于对照组,且血浆Hcy水平与老年痴呆严重程度呈正相关(r=0.898,P<0.05)。结论:血浆Hcy水平与老年痴呆病情程度呈正相关,可作为临床检验与预测老年痴呆病情的指标。

Objective： To investigate the correlation between plasma homoeysteine （Hey） level and the severity of dementia in elderly patients. Methods：A total of 146 elderly patients with dementia in our hospital fronl Oct 2015 to Oct 2017 were enrolled. The patients were divided into mild, moderate and severe with Chinese Version of Mini Mental State Examination （CMMSE）, and divided into vascular dementia （VD）, mixed dementia （MD） and Alzheimer＇s disease （AD） according to the Haehinski isehemia index scale. Another 43 healthy persons in the same period were selected as control group. The plasma Hcy level was detected by eyelie enzymatic method, and the eon＇elation between Hey level and the severity of dementia in elderly patients was analyzed. Results ： The plasma Hey levels in AD, MD and VD groups were significantly higher than those in the control group （P〈0.01）. The plasma Hey level of different degrees of dementia in elderly patients was significantly higher than that in the control group, and the Hey level was positively correlated with the severity of the dementia （r=0.898, P〈0.05）. Conclusions： The plasma Hey level is positivly correlated with the degree of dementia in elderly patients. It can be used as a clinical indicator for the detection and prediction of dementia in elderly patients.